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Literature DB >> 6254011

Uniparental propagation of mitochondrial DNA in mouse-human cell hybrids.

Abstract

The retention of the two parental mitochondrial DNAs has been investigated in a large number of mouse-human cell hybrids segregating either mouse or human chromosomes, by using a highly sensitive and specific method for detection of the DNA; the results have been correlated with the karyotype and isozyme marker pattern in the same hybrid lines. In all the hybrids examined, a consistent pattern was observed for the type of mitochondrial DNA retained: the mitochondrial DNA of the parent whose chromosomes were segregated from the nucleus was undetectable or present in marginal amounts. This was true also of hybrids containing a complete set of the segregating chromosomes in the total or a large fraction of the cell population.

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Year: 1980 PMID： 6254011 PMCID： PMC349773 DOI： 10.1073/pnas.77.7.4079

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

1. Unidirectional loss of human chromosomes in rat-human hybrids.

Authors: C M Croce; I Kieba; H Koprowski
Journal: Exp Cell Res Date: 1973-06 Impact factor: 3.905

2. Propagation of both parental mitochondrial DNAs in rat-human and mouse-human hybrid cells.

Authors: H G Coon; I Horak; I B Dawid
Journal: J Mol Biol Date: 1973-12-15 Impact factor: 5.469

3. Expression of the mitochondrial genome in HeLa cells. 13. Effect of selective inhibition of cytoplasmic or mitochondrial protein synthesis on mitochondrial nucleic acid synthesis.

Authors: B Storrie; G Attardi
Journal: J Mol Biol Date: 1972-11-14 Impact factor: 5.469

4. A rapid banding technique for human chromosomes.

Authors: M Seabright
Journal: Lancet Date: 1971-10-30 Impact factor: 79.321

5. Persistence of thymidine kinase activity in mitochondria of a thymidine kinase-deficient derivative of mouse L cells.

Authors: B Attardi; G Attardi
Journal: Proc Natl Acad Sci U S A Date: 1972-10 Impact factor: 11.205

6. Synthesis of mitochondrial RNA in hamster-mouse hybrid cells.

Authors: G L Eliceiri
Journal: Nat New Biol Date: 1973-02-21

7. Ribosomal RNA synthesis in human-mouse hybrid cells.

Authors: G L Eliceiri; H Green
Journal: J Mol Biol Date: 1969-04 Impact factor: 5.469

8. Membrane-bound ribosomes in HeLa cells. I. Their proportion to total cell ribosomes and their association with messenger RNA.

Authors: B Attardi; B Cravioto; G Attardi
Journal: J Mol Biol Date: 1969-08-28 Impact factor: 5.469

9. Mitochondrial DNA of human-mouse cell hybrids.

Authors: D A Clayton; R L Teplitz; M Nabholz; H Dovey; W Bodmer
Journal: Nature Date: 1971-12-31 Impact factor: 49.962

10. Synthesis of ribosomal RNA in synkaryons and heterokaryons formed between human and rodent cells.

Authors: C J Marshall
Journal: J Cell Sci Date: 1975-03 Impact factor: 5.285

18 in total

1. Sequence polymorphisms within the human mitochondrial genes MTATP6, MTATP8 and MTND4.

Authors: Sabine Lutz-Bonengel; Ulrike Schmidt; Tanja Schmitt; Stefan Pollak
Journal: Int J Legal Med Date: 2003-05-06 Impact factor: 2.686

2. Evaluation of mitochondrial content and activity with nonyl-acridine orange and rhodamine 123: flow cytometric analysis and comparison with quantitative morphometry. Comparative analysis by flow cytometry and quantitative morphometry of mitochondrial content and activity.

Authors: G Lizard; Y Chardonnet; M C Chignol; J Thivolet
Journal: Cytotechnology Date: 1990-03 Impact factor: 2.058

Uniparental propagation of mitochondrial DNA in mouse-human cell hybrids.

1. Unidirectional loss of human chromosomes in rat-human hybrids.

2. Propagation of both parental mitochondrial DNAs in rat-human and mouse-human hybrid cells.

3. Expression of the mitochondrial genome in HeLa cells. 13. Effect of selective inhibition of cytoplasmic or mitochondrial protein synthesis on mitochondrial nucleic acid synthesis.

4. A rapid banding technique for human chromosomes.

5. Persistence of thymidine kinase activity in mitochondria of a thymidine kinase-deficient derivative of mouse L cells.

6. Synthesis of mitochondrial RNA in hamster-mouse hybrid cells.

7. Ribosomal RNA synthesis in human-mouse hybrid cells.

8. Membrane-bound ribosomes in HeLa cells. I. Their proportion to total cell ribosomes and their association with messenger RNA.

9. Mitochondrial DNA of human-mouse cell hybrids.

10. Synthesis of ribosomal RNA in synkaryons and heterokaryons formed between human and rodent cells.

1. Sequence polymorphisms within the human mitochondrial genes MTATP6, MTATP8 and MTND4.

2. Evaluation of mitochondrial content and activity with nonyl-acridine orange and rhodamine 123: flow cytometric analysis and comparison with quantitative morphometry. Comparative analysis by flow cytometry and quantitative morphometry of mitochondrial content and activity.

3. Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids.

4. Interspecies mitochondrial fusion between mouse and human mitochondria is rapid and efficient.

5. Patterns of mitochondrial DNA instability in Brassica campestris cultured cells.

6. Molecular analysis of genomic stability of mitochondrial DNA in tissue cultured cells of maize.

7. mtDNA as a tool for identification of human remains. Identification using mtDNA.

8. Mitochondrial modulation of maternally transmitted antigen: analysis of cell hybrids.

9. Transcription and translation of mitochondrial DNA in interspecific somatic cell hybrids.

10. [Fate of parental mitochondria in embryonic stem hybrid cells].