Literature DB >> 6253679

Generation of nondefective Rous sarcoma virus by asymmetric recombination between deletion mutants.

G S Martin, W H Lee, P H Duesberg.   

Abstract

A replication-defective deletion mutant of Prague Rous sarcoma virus (RSV), which lacks functional gag, pol, and env genes, was crossed with a transformation-defective deletion mutant derived from Schmidt-Ruppin RSV. Transformation- and replication-competent viruses were generated in the cross. Characterization of one of these rescued viruses indicated that it was a nondefective recombinant containing the src gene of the replication-defective mutant plus the replicative genes of the transformation-defective virus. These results indicate that, contrary to previous reports, asymmetric recombination between RSV deletion mutants can result in the formation of nondefective RSV.

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Year:  1980        PMID： 6253679      PMCID： PMC353678     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

1.  Transformation-defective mutants of avian sarcoma viruses: the genetic relationship between conditional and nonconditional mutants.

Authors:  A Bernstein; R MacCormick; G S Martin
Journal:  Virology       Date:  1976-03       Impact factor: 3.616

2.  Transformation-defective mutants of Rous sarcoma virus with src gene deletions of varying length.

Authors:  S Kawai; P H Duesberg; H Hanafusa
Journal:  J Virol       Date:  1977-12       Impact factor: 5.103

3.  RNA species obtained from clonal lines of avian sarcoma and from avian leukosis virus.

Authors:  P H Duesberg; P K Vogt
Journal:  Virology       Date:  1973-07       Impact factor: 3.616

4.  Genetically stable reassortment of markers during mixed infection with avian tumor viruses.

Authors:  P K Vogt
Journal:  Virology       Date:  1971-12       Impact factor: 3.616

5.  Genetic recombination with avian tumor virus.

Authors:  S Kawai; H Hanafusa
Journal:  Virology       Date:  1972-07       Impact factor: 3.616

6.  Recombination between a temperature-sensitive mutant and a deletion mutant of Rous sarcoma virus.

Authors:  S Kawai; H Hanafusa
Journal:  J Virol       Date:  1976-08       Impact factor: 5.103

7.  Distribution of envelope-specific and sarcoma-specific nucleotide sequences from different parents in the RNAs of avian tumor virus recombinants.

Authors:  L H Wang; P Duesberg; P Mellon; P K Vogt
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

8.  Mapping RNase T1-resistant oligonucleotides of avian tumor virus RNAs: sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(A) end.

Authors:  L H Wang; P Duesberg; K Beemon; P K Vogt
Journal:  J Virol       Date:  1975-10       Impact factor: 5.103

9.  Location of envelope-specific and sarcoma-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus.

Authors:  L H Wang; P H Duesberg; S Kawai; H Hanafusa
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205

10.  Isolation of defective mutant of avian sarcoma virus.

Authors:  S Kawai; H Hanafusa
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205
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  5 in total

1.  Phosphorylation of talin at tyrosine in Rous sarcoma virus-transformed cells.

Authors:  J E DeClue; G S Martin
Journal:  Mol Cell Biol       Date:  1987-01       Impact factor: 4.272

2.  Transduction of proto-src sequences in tissue culture by a molecular clone of transformation-defective Rous sarcoma virus with an internal src deletion.

Authors:  W Phares
Journal:  J Virol       Date:  1988-12       Impact factor: 5.103

3.  Evidence that retroviral transduction is mediated by DNA not by RNA.

Authors:  D W Goodrich; P H Duesberg
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

4.  src Genes of ten Rous sarcoma virus strains, including two reportedly transduced from the cell, are completely allelic; putative markers of transduction are not detected.

Authors:  W H Lee; M Nunn; P H Duesberg
Journal:  J Virol       Date:  1981-09       Impact factor: 5.103

5.  Selective killing of HIV-1-positive macrophages and T cells by the Rev-dependent lentivirus carrying anthrolysin O from Bacillus anthracis.

Authors:  Jessica Young; Zhongwei Tang; Quan Yu; Dongyang Yu; Yuntao Wu
Journal:  Retrovirology       Date:  2008-04-25       Impact factor: 4.602
  5 in total

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