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Literature DB >> 6252865

DNA synthesis in chromatin preparations from human fibroblasts infected by cytomegalovirus.

Abstract

Chromatin prepared from (14C)-thymidine pulse labelled cytomegalovirus-infected human fibroblasts 72 hours postinfection exhibited under appropriate conditions endogenous activity of (3H)-thymidine triphosphate incorporation which was relatively salt-resistant and phosphonoacetic acid-sensitive. Isopycnic centrifugation of the doubly labelled DNA in CsCl revealed that cell-free incoporation occurred into viral as well as into host cell DNA. Density labelling experiments with bromodeoxyuridine triphosphate suggested the incoporation into viral DNA to be due to replicative DNA synthesis. Chromatin from infected cells contained, in addition to cellular, viral DNA polymerase activity.

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Year: 1980 PMID： 6252865 DOI： 10.1007/bf01340539

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

22 in total

6. Adenovirus deoxyribonucleic acid replication. Characterization of the enzyme activities of a soluble replication system.

Authors: M Arens; T Yamashita; R Padmanabhan; T Tsuruo; M Green
Journal: J Biol Chem Date: 1977-11-25 Impact factor: 5.157

7. Effect of herpes simplex virus type 1 infection on the cellular DNA polymerase activities of mouse cell cultures.

Authors: K Radsak
Journal: J Gen Virol Date: 1978-12 Impact factor: 3.891

8. A cell-free assay measuring repair DNA synthesis in human fibroblasts.

Authors: G Ciarrocchi; S Linn
Journal: Proc Natl Acad Sci U S A Date: 1978-04 Impact factor: 11.205

9. Growth characteristics of cytomegalovirus in human fibroblasts with demonstration of protein synthesis early in viral replication.

Authors: T Furukawa; A Fioretti; S Plotkin
Journal: J Virol Date: 1973-06 Impact factor: 5.103

10. Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid.

Authors: E S Huang
Journal: J Virol Date: 1975-12 Impact factor: 5.103

5 in total

1. Dissociation between cellular DNA- and histone synthesis following infection by cytomegalovirus in the presence of phosphonoacetic acid.

Authors: K Radsak; D Weder
Journal: Arch Virol Date: 1981 Impact factor: 2.574

2. Actin distribution and synthesis in human fibroblasts infected by cytomegalovirus.

Authors: D Lösse; R Lauer; D Weder; K Radsak
Journal: Arch Virol Date: 1982 Impact factor: 2.574

3. Abstracts of papers presented at the 5th Workshop of the Virology Section of the Deutsche Gesellschaft für Hygiene und Mikrobiologie, Tübingen, December 4-6, 1980.

Authors:
Journal: Med Microbiol Immunol Date: 1981 Impact factor: 3.402

4. Unimpaired histone synthesis in human fibroblasts infected by human cytomegalovirus.

Authors: K Radsak; B Schmitz
Journal: Med Microbiol Immunol Date: 1980-02 Impact factor: 3.402

5. Inhibition by monensin of human cytomegalovirus DNA replication.

Authors: C J Kaiser; K Radsak
Journal: Arch Virol Date: 1987 Impact factor: 2.574