Literature DB >> 6252471

Resolution, reconstitution and kinetics of the primary action of a hormone receptor.

Y Citri, M Schramm.   

Abstract

The beta-adrenergic receptor (R) and the GTP binding protein (G) with which the receptor interacts were obtained in separate soluble fractions. Their recombination produced a hormone responsive system. In the presence of hormone the encounter of R with G in the reconstituted membrane occurs much faster than the subsequent R-induced activation of G.

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Year:  1980        PMID： 6252471     DOI： 10.1038/287297a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  27 in total

Review 1.  G protein coupling of receptors to ionic channels and other effector systems.

Authors:  L Birnbaumer; A Yatani; A M VanDongen; R Graf; J Codina; K Okabe; R Mattera; A M Brown
Journal:  Br J Clin Pharmacol       Date:  1990       Impact factor: 4.335

Review 2.  Coupling mode of receptors and G proteins.

Authors:  Peter Hein; Moritz Bünemann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-12-02       Impact factor: 3.000

Review 3.  The role of G proteins in transmembrane signalling.

Authors:  C W Taylor
Journal:  Biochem J       Date:  1990-11-15       Impact factor: 3.857

Review 4.  Signal transduction in hormone-dependent adenylate cyclase.

Authors:  A Levitzki
Journal:  Cell Biophys       Date:  1988 Jan-Jun

5.  An estimate of the number of G regulator proteins activated per excited rhodopsin in living Limulus ventral photoreceptors.

Authors:  A Kirkwood; D Weiner; J E Lisman
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

Review 6.  Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase.

Authors:  A G Gilman
Journal:  J Clin Invest       Date:  1984-01       Impact factor: 14.808

7.  Lateral motion of beta receptors in membranes of cultured liver cells.

Authors:  Y I Henis; M Hekman; E L Elson; E J Helmreich
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

8.  Stimulatory GTP regulatory unit Ns and the catalytic unit of adenylate cyclase are tightly associated: mechanistic consequences.

Authors:  H Arad; J P Rosenbusch; A Levitzki
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

9.  Functional reconstitution of beta-adrenergic receptors and the stimulatory GTP-binding protein of adenylate cyclase.

Authors:  S E Pedersen; E M Ross
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

10.  Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes.

Authors:  A Richardson; C Demoliou-Mason; E A Barnard
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205
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