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Literature DB >> 6252042

The mechanical and biochemical effects of pentoxifylline on the perfused rat heart.

L Vittone, L E Chiappe, M I Argel, H E Cingolani, G E Chiappe.

Abstract

Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.

Entities: Chemical Species

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Year: 1980 PMID： 6252042 DOI： 10.1007/bf01965986

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

23 in total

1. AN IMPROVED METHOD FOR FLUORIMETRIC DETERMINATION OF SMALL AMOUNTS OF ADRENALINE AND NORADRENALINE IN PLASMA AND TISSUES.

Authors: J HAEGGENDAL
Journal: Acta Physiol Scand Date: 1963-11

2. The potentiation of cardiac inotropic responses to norepinephrine by theophylline.

Authors: T W RALL; T C WEST
Journal: J Pharmacol Exp Ther Date: 1963-03 Impact factor: 4.030

3. Are increases in cyclic GMP levels responsible for the negative inotropic effects of acetylcholine in the heart?

Authors: J Diamond; R E Ten Eick; A J Trapani
Journal: Biochem Biophys Res Commun Date: 1977-12-07 Impact factor: 3.575

Review 4. Cyclic AMP and contractile activity in heart.

Authors: R W Tsien
Journal: Adv Cyclic Nucleotide Res Date: 1977

Review 5. Cyclic nucleotide phosphodiesterases.

Authors: M M Appleman; W J Thompson; T R Russell
Journal: Adv Cyclic Nucleotide Res Date: 1973

6. Influence of acetylcholine on contractile force and cyclic nucleotide levels in the isolated perfused rat heart.

Authors: W J George; R D Wilkerson; P J Kadowitz
Journal: J Pharmacol Exp Ther Date: 1973-01 Impact factor: 4.030

7. Radioimmunoassay for cyclic nucleotides. II. Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in mammalian tissues and body fluids.

Authors: A L Steiner; A S Pagliara; L R Chase; D M Kipnis
Journal: J Biol Chem Date: 1972-02-25 Impact factor: 5.157

8. Cyclic AMP and calcium uptake of the sarcoplasmic reticulum in relation to increased rate of relaxation under the influence of catecholamines.

Authors: E Shinebourne; R White
Journal: Cardiovasc Res Date: 1970-04 Impact factor: 10.787

The mechanical and biochemical effects of pentoxifylline on the perfused rat heart.

1. AN IMPROVED METHOD FOR FLUORIMETRIC DETERMINATION OF SMALL AMOUNTS OF ADRENALINE AND NORADRENALINE IN PLASMA AND TISSUES.

2. The potentiation of cardiac inotropic responses to norepinephrine by theophylline.

3. Are increases in cyclic GMP levels responsible for the negative inotropic effects of acetylcholine in the heart?

Review 4. Cyclic AMP and contractile activity in heart.

Review 5. Cyclic nucleotide phosphodiesterases.

6. Influence of acetylcholine on contractile force and cyclic nucleotide levels in the isolated perfused rat heart.

7. Radioimmunoassay for cyclic nucleotides. II. Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in mammalian tissues and body fluids.

8. Cyclic AMP and calcium uptake of the sarcoplasmic reticulum in relation to increased rate of relaxation under the influence of catecholamines.

9. Relation between mechanics of contraction and relaxation in mammalian cardiac muscle.

10. Effect of isoproterenol on relation between maximal rate of contraction and maximal rate of relaxation.

1. Phosphodiesterase inhibition promotes the transition from compensated hypertrophy to cardiac dilatation in rats.

Review 2. [Anti-inflammatory effects of pentoxifylline: importance in cardiac surgery].