Literature DB >> 6252037

Brain cyclic nucleotide and energy metabolite responses to subanesthetic and anesthetic concentrations of halothane.

P Divakaran, B M Rigor, R C Wiggins.   

Abstract

Adult rats were exposed to 0.5, 1.0 and 1.5% halothane, delivered in air, for 1 h. Whole brain 3',5'-cyclic adenosine monophosphate (cAMP) of halothane-exposed rats showed only a slight increase relative to control values. 3',5'-Cyclic guanosine monophosphate (cGMP) was increased significantly in halothane-exposed rats, and the response was directly related to the halothane concentrations. Adenosine triphosphate (ATP) and phosphocreatine (PC) remained unchanged relative to control values. Correspondence of these values to apparent discrepancies in the literature is discussed.

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Year:  1980        PMID： 6252037     DOI： 10.1007/bf01970119

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Dopamine-sensitive adenylate cyclase activity in the rat caudate nucleus during exposure to halothane and enflurane.

Authors:  S Y Woo; M Verosky; Y Vulliemoz; L Triner
Journal:  Anesthesiology       Date:  1979-07       Impact factor: 7.892

2.  Use of a rapid brain-sampling technique in a physiologic preparation: effects of morphine, ketamine, and halothane on tissue energy intermediates.

Authors:  D F Dedrick; Y D Sherer; J F Biebuyck
Journal:  Anesthesiology       Date:  1975-06       Impact factor: 7.892

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Halothane-induced alterations of cyclic nucleotide concentrations in three regions of the mouse nervous system.

Authors:  M L Nahrwold; W D Lust; J V Passonneau
Journal:  Anesthesiology       Date:  1977-11       Impact factor: 7.892

5.  Radioimmunoassay for cyclic nucleotides. II. Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in mammalian tissues and body fluids.

Authors:  A L Steiner; A S Pagliara; L R Chase; D M Kipnis
Journal:  J Biol Chem       Date:  1972-02-25       Impact factor: 5.157

6.  Radioimmunoassay for cyclic nucleotides. 3. Effect of ischemia, changes during development and regional distribution of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in mouse brain.

Authors:  A L Steiner; J A Ferrendelli; D M Kipnis
Journal:  J Biol Chem       Date:  1972-02-25       Impact factor: 5.157

7.  A rapid and simple procedure for the determination of guanosine 3',5'-monophosphate by use of the protein-binding method.

Authors:  V Dinnendahl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

Review 8.  Cyclic nucleotides in nervous tissue.

Authors:  V M Wiegant
Journal:  Brain Res Bull       Date:  1978 Nov-Dec       Impact factor: 4.077

9.  Cyclic adenosine monphosphate, metabolites, and phosphorylase in neural tissue: a comparison a methods of fixation.

Authors:  W D Lust; J V Passonneau; R L Veech
Journal:  Science       Date:  1973-07-20       Impact factor: 47.728

10.  A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate.

Authors:  F Murad; V Manganiello; M Vaughan
Journal:  Proc Natl Acad Sci U S A       Date:  1971-04       Impact factor: 11.205
  10 in total
  1 in total

1.  Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha.

Authors:  Yasuko Nagasaka; Martin Wepler; Robrecht Thoonen; Patrick Y Sips; Kaitlin Allen; Jan A Graw; Vincent Yao; Sara M Burns; Stefan Muenster; Peter Brouckaert; Keith Miller; Ken Solt; Emmanuel S Buys; Fumito Ichinose; Warren M Zapol
Journal:  BMC Anesthesiol       Date:  2017-06-14       Impact factor: 2.217
  1 in total

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