Literature DB >> 6252023

Harmaline-induced tremor: the benzodiazepine receptor as a site of action.

H A Robertson.   

Abstract

Harmaline produces a tremor which is prevented by diazepam. This beta-carboline also displaces specifically bound 3H-flunitrazepam from the benzodiazepine receptor. While harmaline has a low affinity for the receptor (IC50 approximately 600 micro M), tremorogenic (i.p.) doses of harmaline produce brain concentrations sufficient to occupy some benzodiazepine binding sites. It is suggested that part of harmaline's actions may be the results of an interaction with the benzodiazepine receptor.

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Year:  1980        PMID： 6252023     DOI： 10.1016/0014-2999(80)90020-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  15 in total

1.  Ca(V)3.1 is a tremor rhythm pacemaker in the inferior olive.

Authors:  Young-Gyun Park; Hye-Yeon Park; C Justin Lee; Soonwook Choi; Seonmi Jo; Hansol Choi; Yang-Hann Kim; Hee-Sup Shin; Rodolfo R Llinas; Daesoo Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-24       Impact factor: 11.205

2.  Monoclonal antibody to 2-amino-3-methylimidazo(4,5-f)quinoline, a dietary carcinogen.

Authors:  H Yanagisawa; T Tachikawa; S Shin; O Wada
Journal:  Appl Biochem Biotechnol       Date:  1990-01       Impact factor: 2.926

3.  Anti-Tremor Action of Subtype Selective Positive Allosteric Modulators of GABAA Receptors in a Rat Model of Essential Tremors.

Authors:  Dipak V Amrutkar; Tino Dyhring; Thomas A Jacobsen; Janus S Larsen; Karin Sandager-Nielsen
Journal:  Cerebellum       Date:  2020-04       Impact factor: 3.847

4.  Blood harmane concentrations and dietary protein consumption in essential tremor.

Authors:  E D Louis; W Zheng; L Applegate; L Shi; P Factor-Litvak
Journal:  Neurology       Date:  2005-08-09       Impact factor: 9.910

5.  Relationship between blood harmane and harmine concentrations in familial essential tremor, sporadic essential tremor and controls.

Authors:  Elan D Louis; Wendy Jiang; Marina Gerbin; Mary M Mullaney; Wei Zheng
Journal:  Neurotoxicology       Date:  2010-08-11       Impact factor: 4.294

6.  Blood harmane, blood lead, and severity of hand tremor: evidence of additive effects.

Authors:  Elan D Louis; Pam Factor-Litvak; Marina Gerbin; Vesna Slavkovich; Joseph H Graziano; Wendy Jiang; Wei Zheng
Journal:  Neurotoxicology       Date:  2010-12-08       Impact factor: 4.294

Review 7.  From neurons to neuron neighborhoods: the rewiring of the cerebellar cortex in essential tremor.

Authors:  Elan D Louis
Journal:  Cerebellum       Date:  2014-08       Impact factor: 3.847

8.  Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.

Authors:  Adam L Halberstadt; Mahalah R Buell; Virginia L Masten; Victoria B Risbrough; Mark A Geyer
Journal:  Psychopharmacology (Berl)       Date:  2008-07-08       Impact factor: 4.530

Review 9.  Environmental epidemiology of essential tremor.

Authors:  Elan D Louis
Journal:  Neuroepidemiology       Date:  2008-08-21       Impact factor: 3.282

10.  Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor.

Authors:  Elan D Louis; Wendy Jiang; Kathryn M Pellegrino; Eileen Rios; Pam Factor-Litvak; Claire Henchcliffe; Wei Zheng
Journal:  Neurotoxicology       Date:  2007-12-27       Impact factor: 4.294
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