Literature DB >> 6252000

Anomalous plasma cyclic AMP responses to glucagon in patients with liver disease.

H Maekubo, T Matsushima, F Okada, M Honma, M Ui.   

Abstract

The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. This glucagon test is, therefore, promising for development as a simple diagnostic means without undertaking liver biopsy to distinguish cirrhosis from chronic hepatitis.

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Year:  1980        PMID： 6252000     DOI： 10.1007/bf01308330

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  17 in total

1.  Increases in plasma cyclic AMP dependent on endogenous catecholamines.

Authors:  S Kunitada; M Honma; M Ui
Journal:  Eur J Pharmacol       Date:  1978-03-15       Impact factor: 4.432

2.  Plasma cyclic AMP levels during a secretin-caerulein pancreatic function test in liver and pancreatic disease.

Authors:  M Adler; P Robberecht; M G Poitevin; J Christophe
Journal:  Gut       Date:  1978-03       Impact factor: 23.059

3.  An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue.

Authors:  M Honma; T Satoh; J Takezawa; M Ui
Journal:  Biochem Med       Date:  1977-12

4.  Adrenergic and cholinergic modulation of extracellular cyclic nucleotides.

Authors:  M Ui; M Honma; S Kunitada; F Okada; H Ide; S Hata; T Satoh
Journal:  Adv Cyclic Nucleotide Res       Date:  1980

5.  Effect of glucagon infusion on plasma cyclic AMP in patients with cholestatic hepatitis and obstructive jaundice. New test of hepatic cholestasis.

Authors:  A Francavilla; F Pansini; F Sansone; O Albano; G Martellotta
Journal:  Clin Chim Acta       Date:  1977-03-15       Impact factor: 3.786

6.  The cyclic AMP response to glucagon. Comparison of tissue and plasma cyclic AMP levels in the rabbit.

Authors:  G Jerums; K J Hardy; J A Eisman
Journal:  Diabetes       Date:  1977-02       Impact factor: 9.461

7.  Hyperglucagonemia and altered responsiveness of hepatic adenylate cyclase-adenosine 3',5'-monophosphate system to hormonal stimulation during chronic ingestion of DL-ethionine.

Authors:  P A Craven; F R Derubertis
Journal:  Biochim Biophys Acta       Date:  1977-04-27

8.  Thyroid function and plasma cyclic AMP response to intravenous glucagon.

Authors:  S N Madsen
Journal:  Acta Endocrinol (Copenh)       Date:  1977-08

9.  Effect of glucagon on net splanchnic cyclic AMP production in normal and diabetic men.

Authors:  J E Liljenquist; J D Bomboy; S B Lewis; B C Sinclair-Smith; P W Felts; W W Lacy; O B Crofford; G W Liddle
Journal:  J Clin Invest       Date:  1974-01       Impact factor: 14.808

10.  Effects of glucagon on adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in human plasma and urine.

Authors:  A E Broadus; N I Kaminsky; R C Northcutt; J G Hardman; E W Sutherland; G W Liddle
Journal:  J Clin Invest       Date:  1970-12       Impact factor: 14.808
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