| Literature DB >> 6251967 |
Abstract
Effect of dibutyryl cyclic adenosine 3'5'-monophosphate (dbcAMP) on mitotic activity in the thyroid of hypophysectomized rats has been examined. It has been demonstrated that dbcAMP stimulates the incidence of mitoses in the thyroid follicular cells. It is therefore suggested that cAMP may be a mediator of the proliferogenic effect of TSH on the thyroid in vivo. Cyclic AMP could also release some unidentified growth-promoting factors for the thyroid. A direct stimulating effect of dbcAMP on the proliferation of the thyroid follicular cells is assumed to be possible as well.Entities:
Mesh：
Substances：
Year: 1980 PMID： 6251967 DOI： 10.1007/bf00236455
Source DB: PubMed Journal: Cell Tissue Res ISSN： 0302-766X Impact factor: 5.249