| Literature DB >> 6251905 |
P Mangeat, G Marchis-Mouren, A M Cheret, M J Lewin.
Abstract
Histamine stimulated cyclic AMP-dependent protein kinase activity in dispersed mucosal cells from guinea-pig gastric fundus (Ka = 5 microM). The H2-agonists dimaprit and impromidine produced similar effects, while the H1-agonist 2-(2-pyridyl) ethylamine had only a weak one. The H2-antagonist cimetidine competitively inhibited 0.1 mM histamine stimulation (Ki = 2 microM). In contrast, the H1-antagonist diphenhydramine had no effect up to 1 mM.Entities:
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Year: 1980 PMID： 6251905 DOI： 10.1016/0304-4165(80)90165-8
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002