Literature DB >> 6251364

Ca-activated neutral protease and its inhibitors: in vitro effect on intact myofibrils.

H Sugita, S Ishiura, K Suzuki, K Imahori.   

Abstract

SDS gel electrophoresis of troponin and myosin extracted from chicken myofibrils pretreated with Ca-activated neutral protease showed a pattern similar to that observed in the muscles of patients with Duchenne muscular dystrophy, that is, a decrease in troponin-I and troponin-C with relative preservation of troponin-T and degradation of the heavy chain of myosin. Also, alpha-actinin and troponin-C were released from myofibrils. Two inhibitors of Ca-activated neutral protease, leupeptin and E-64, inhibited the degradative action of Ca-activated neutral protease on intact myofibrils in vitro.

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Year:  1980        PMID： 6251364     DOI： 10.1002/mus.880030410

Source DB:  PubMed          Journal:  Muscle Nerve        ISSN： 0148-639X            Impact factor:   3.217


  18 in total

1.  Ultrastructural study of the effect of calcium ionophore, A23187, on rat muscle.

Authors:  T Yoshimura; M Tsujihata; A Satoh; M Mori; R Hazama; N Kinoshita; H Takashima; S Nagataki
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

2.  The effects of a calcium dependent protease on the ultrastructure and contractile mechanics of skinned uterine smooth muscle.

Authors:  J R Haeberle; S A Coolican; A Evan; D R Hathaway
Journal:  J Muscle Res Cell Motil       Date:  1985-06       Impact factor: 2.698

3.  Effect of soluble factors from nerve and muscle on alpha-bungarotoxin binding sites in isolated sarcolemmal membranes of the rat.

Authors:  A J Harborne; M E Smith
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

4.  Digestion of proteins associated with the Z-disc by calpain.

Authors:  B Bullard; G Sainsbury; N Miller
Journal:  J Muscle Res Cell Motil       Date:  1990-06       Impact factor: 2.698

5.  Correlative study of the incidence of opaque, necrotic and regenerative fibers in Duchenne dystrophy.

Authors:  M Uchino; S Araki; T Miike
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

6.  Role of Ca2+ for protein turnover in isolated rat hepatocytes.

Authors:  B Grinde
Journal:  Biochem J       Date:  1983-12-15       Impact factor: 3.857

Review 7.  Contractile proteins in muscle disease.

Authors:  P Cummins
Journal:  J Muscle Res Cell Motil       Date:  1983-02       Impact factor: 2.698

8.  Immunohistochemical study of calpain and its endogenous inhibitor in the skeletal muscle of muscular dystrophy.

Authors:  T Kumamoto; H Ueyama; S Watanabe; K Yoshioka; T Miike; D E Goll; M Ando; T Tsuda
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

9.  Therapeutic trial with protease inhibitor (leupeptin) in chicken muscular dystrophy. A histologic and histochemical study.

Authors:  I Nonaka; S Ishiura; A Takagi; H Sugita
Journal:  Acta Neuropathol       Date:  1982       Impact factor: 17.088

10.  In vivo effects of protease inhibitors on chickens with hereditary muscular dystrophy.

Authors:  M S Hudecki; C M Pollina; R R Heffner
Journal:  J Clin Invest       Date:  1981-04       Impact factor: 14.808
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