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Literature DB >> 6251242

Distinct transformation phenotypes induced by polyoma virus and simian virus 40 in rat fibroblasts and their control by an early viral gene function.

Abstract

Several transformed cell lines established from Fisher rat cells (FR 3T3) infected with wild-type polyoma virus or simian virus 40 or early temperature-sensitive mutants (polyoma tsa and simian virus 40 tsA30) were studied for their transformation phenotypes. The distinct patterns which were obtained for polyoma and simian virus 40 transformants led to the conclusion that these two viruses express different transforming abilities in rat cells. The results obtained with temperature-sensitive mutant-derived transformants indicate that all of the transformation characteristics studied so far may be under the control of a viral function in polyoma tsa-transformed cells.

Entities: Disease Species

Mesh：

Substances：

Year: 1980 PMID： 6251242 PMCID： PMC288594

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

18 in total

1. Steps in the neoplastic transformation of hamster embryo cells by polyoma virus.

Authors: M VOGT; R DULBECCO
Journal: Proc Natl Acad Sci U S A Date: 1963-02-15 Impact factor: 11.205

2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

3. A nonselective analysis of SV40 transformation of mouse 3T3 cells.

Authors: R Risser; R Pollack
Journal: Virology Date: 1974-06 Impact factor: 3.616

4. Increased protease levels in transformed cells: a casein overlay assay for the detection of plasminogen activator production.

Authors: A R Goldberg
Journal: Cell Date: 1974-06 Impact factor: 41.582

5. Radioactive labeling of proteins in vitro.

Authors: R H Rice; G E Means
Journal: J Biol Chem Date: 1971-02-10 Impact factor: 5.157

6. A simple colorimetric method for determination of protein.

Authors: S Bramhall; N Noack; M Wu; J R Loewenberg
Journal: Anal Biochem Date: 1969-10-01 Impact factor: 3.365

7. Phorbol ester-induced morphological changes in transformed chick fibroblasts: evidence for direct catalytic involvement of plasminogen activator.

Authors: J P Quigley
Journal: Cell Date: 1979-05 Impact factor: 41.582

8. Fibrinolytic activity in a human fibrosarcoma cell line and evidence for the induction of plasminogen activator secretion during tumor formation.

Authors: P A Jones; W E Laug; W F Benedict
Journal: Cell Date: 1975-10 Impact factor: 41.582

2. Transformation phenotype of polyoma virus-transformed rat fibroblasts: plasminogen activator production is modulated by the growth state of the cells and regulated by the expression of an early viral gene function.

Authors: B Perbal
Journal: J Virol Date: 1980-08 Impact factor: 5.103

3. Insufficiency of transformation by simian virus 40, polyomavirus, EJ-ras, or v-myc oncogenes for conversion of ethanolamine-responsive mammary cells to ethanolamine-nonresponsive cells.

Authors: T Kano-Sueoka; D M King
Journal: J Virol Date: 1988-09 Impact factor: 5.103

Distinct transformation phenotypes induced by polyoma virus and simian virus 40 in rat fibroblasts and their control by an early viral gene function.

1. Steps in the neoplastic transformation of hamster embryo cells by polyoma virus.

2. Protein measurement with the Folin phenol reagent.

3. A nonselective analysis of SV40 transformation of mouse 3T3 cells.

4. Increased protease levels in transformed cells: a casein overlay assay for the detection of plasminogen activator production.

5. Radioactive labeling of proteins in vitro.

6. A simple colorimetric method for determination of protein.

7. Phorbol ester-induced morphological changes in transformed chick fibroblasts: evidence for direct catalytic involvement of plasminogen activator.

8. Fibrinolytic activity in a human fibrosarcoma cell line and evidence for the induction of plasminogen activator secretion during tumor formation.

9. Rous-sarcoma-virus-transformed fibroblasts having low levels of plasminogen activator.

10. Production of plasminogen activator by established cell lines of mouse origin.

1. Effect of tissue culture variables on sister chromatid exchange in a nontransformed rat cell line.

2. Transformation phenotype of polyoma virus-transformed rat fibroblasts: plasminogen activator production is modulated by the growth state of the cells and regulated by the expression of an early viral gene function.

3. Insufficiency of transformation by simian virus 40, polyomavirus, EJ-ras, or v-myc oncogenes for conversion of ethanolamine-responsive mammary cells to ethanolamine-nonresponsive cells.

4. Polyoma virus middle t antigen: a tumor progression factor.

5. Cell cycle-dependent expression of early viral genes in one group of simian virus 40-transformed rat cells.

6. Transforming but not immortalizing oncogenes activate the transcription factor PEA1.