Literature DB >> 6251201

Characteristics of histamine release evoked by acetylcholine in isolated rat mast cells.

P Blandina, R Fantozzi, P F Mannaioni, E Masini.   

Abstract

1. Histamine secretion from rat mast cells occurs in the presence of nanomolar concentrations of acetylcholine. 2. Intact glycolytic and oxidative metabolism is required for the acetylcholine-induced histamine secretion. Removal of extracellular glucose, hypoxia, cyanide and monoiodoacetate almost completely inhibit the secretion. 3. The secretion of histamine is dependent on the extracellular H ion concentration and is blocked when the cells are exposed to Na-deficient media. 4. The order of potency of cholinrgic agonists in evoking the secretion of histamine is oxotremorine > acetylcholine > choline > carbamycholine > nicotine. 5. Atropine competitively blocks the acetylcholine-induced histamine secretion, indicating the presence of cholinergic muscarinic receptors on mast cells. 6. Dibutyryl cyclic AMP and adrenaline inhibit the acetylcholine-induced histamine secretion, indicating a regulatory function afforded by cyclic nucleotides in the cholinergic histamine release.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6251201      PMCID： PMC1279398          DOI： 10.1113/jphysiol.1980.sp013205

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  47 in total

1.  MECHANISM OF ACTION OF RESERPINE AND INSULIN ON GASTRIC AMINES AND GASTRIC ACID SECRETION, AND THE EFFECT OF MONOAMINE OXIDASE INHIBITION.

Authors:  K S KIM; P A SHORE
Journal:  J Pharmacol Exp Ther       Date:  1963-09       Impact factor: 4.030

2.  The mechanism of histamine release in anaphylactic reaction in guinea pig and rat.

Authors:  N CHAKRAVARTY
Journal:  Acta Physiol Scand       Date:  1960-03-18

3.  Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate.

Authors:  L J Ignarro
Journal:  J Immunol       Date:  1974-01       Impact factor: 5.422

4.  Immunologic release of chemical mediators from human nasal polyps.

Authors:  M Kaliner; S I Wasserman; K F Austen
Journal:  N Engl J Med       Date:  1973-08-09       Impact factor: 91.245

5.  Energy production in rat mast cells and its role for histamine release.

Authors:  B Diamant
Journal:  Int Arch Allergy Appl Immunol       Date:  1975

6.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1959-03

Review 7.  Pharmacological aspects of immune reactions.

Authors:  W Schmutzler
Journal:  Allergol Immunopathol (Madr)       Date:  1978 Jul-Aug       Impact factor: 1.667

8.  Adenosine 3'5'-monophosphate: inhibition of complement-mediated cell lysis.

Authors:  M Kaliner; K F Austen
Journal:  Science       Date:  1974-02-15       Impact factor: 47.728

9.  Sodium ions and the secretion of catecholamines.

Authors:  P Banks; R Biggins; R Bishop; B Christian; N Currie
Journal:  J Physiol       Date:  1969-02       Impact factor: 5.182

10.  Regulation of cyclic nucleotide levels and glycogen phosphorylase activity by acetylcholine and epinephrine in perfused rat hearts.

Authors:  R M Gardner; D O Allen
Journal:  J Pharmacol Exp Ther       Date:  1976-08       Impact factor: 4.030
View more
  34 in total

1.  Rat mast cells synthesize a nitric oxide like-factor which modulates the release of histamine.

Authors:  E Masini; D Salvemini; A Pistelli; P F Mannaioni; J R Vane
Journal:  Agents Actions       Date:  1991-05

2.  Immunological modulation of cholinergic histamine release in isolated rat mast cells.

Authors:  E Masini; R Fantozzi; A Conti; P Blandina; S Brunelleschi; P F Mannaioni
Journal:  Agents Actions       Date:  1985-04

Review 3.  Pharmacological studies of pulmonary anaphylaxis in vitro: a review.

Authors:  P O Ogunbiyi; P Eyre
Journal:  Agents Actions       Date:  1985-12

4.  The release of histamine by parasympathetic stimulation in guinea-pig auricle and rat ileum.

Authors:  T Bani-Sacchi; M Barattini; S Bianchi; P Blandina; S Brunelleschi; R Fantozzi; P F Mannaioni; E Masini
Journal:  J Physiol       Date:  1986-02       Impact factor: 5.182

5.  Reversible rat mesenteric mast cell swelling caused by vagal stimulation or sham-feeding.

Authors:  A M Rothschild; E L Gomes; M A Rossi
Journal:  Agents Actions       Date:  1991-11

6.  Histamine release by free radicals: paracetamol-induced histamine release from rat peritoneal mast cells after in vitro activation by monooxygenase.

Authors:  E Masini; M Lodovici; R Fantozzi; S Brunelleschi; A Conti; P F Mannaioni
Journal:  Agents Actions       Date:  1986-04

7.  Histamine release from serosal mast cells by intermediate products of arachidonic acid metabolism.

Authors:  E Masini; E Giannella; T Bani-Sacchi; R Fantozzi; B Palmerani; P F Mannaioni
Journal:  Agents Actions       Date:  1987-04

8.  Helicobacter pylori potentiates histamine release from serosal rat mast cells in vitro.

Authors:  P Bechi; R Dei; M G Di Bello; E Masini
Journal:  Dig Dis Sci       Date:  1993-05       Impact factor: 3.199

9.  Mast cell degranulating (MCD) peptide analogs with reduced ring structure.

Authors:  A Buku; J Reibman; A Pistelli; P Blandina; D Gazis
Journal:  J Protein Chem       Date:  1992-06

10.  Correlation between cholinergic histamine release and quinuclidinyl-benzilate ([3H]-QNB) binding in mast cell membranes.

Authors:  E Masini; P Blandina; R Fantozzi; S Brunelleschi; P F Mannaioni
Journal:  Agents Actions       Date:  1981-04
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.