| Literature DB >> 6251113 |
R V Farese, P Bidot-López, A Sabir, J S Smith, B Schinbeckler, R Larson.
Abstract
Parathyroid hormone(PTH) rapidly increases the concentrations of diphosphoinositide and triphosphoinositide in rabbit kidney cortex. Cycloheximide pretreatment abolishes these effects of PTH. These findings are similar to those reported for adrenocorticotropin and cyclic AMP action in the adrenal cortex, and suggest a common mechanism. Cycloheximide-sensitive effects of PTH, e.g., phosphaturia, may require polyphosphoinositides and/or other phospholipids.Entities:
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Year: 1980 PMID: 6251113 PMCID: PMC371492 DOI: 10.1172/JCI109818
Source DB: PubMed Journal: J Clin Invest ISSN: 0021-9738 Impact factor: 14.808