Literature DB >> 6250538

Consequences of hormone-induced desensitization of adenylate cyclase in intact cells.

S Swillens, E Lefort, R Barber, R W Butcher, J E Dumont.   

Abstract

A hypothesis on the role of the hormone-induced desensitization of adenylate cyclase is proposed. It is suggested that the desensitization process could provide the cell with a highly efficient cyclic AMP system for transmitting hormone stimulus without requiring a large energy consumption. Theoretical considerations show that in fact the desensitization phenomenon allows the cyclic AMP system to present a good compromise between the efficiency and economy requirements of the cells.

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Year:  1980        PMID： 6250538      PMCID： PMC1162552          DOI： 10.1042/bj1880169

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  THE EFFECT OF L-EPINEPHRINE AND OTHER AGENTS ON THE SYNTHESIS AND RELEASE OF ADENOSINE 3',5'-PHOSPHATE BY WHOLE PIGEON ERYTHROCYTES.

Authors:  P R DAVOREN; E W SUTHERLAND
Journal:  J Biol Chem       Date:  1963-09       Impact factor: 5.157

2.  Protein-bound adenosine 3':5'-monophosphate in liver of glucagon-treated rats. Determination of half-maximal binding in vivo and correlation with protein kinase activation.

Authors:  G Schwoch; H Hilz
Journal:  Eur J Biochem       Date:  1977-06-01

3.  Beta adrenergic regulation of glycogen phosphorylase activity and adenosine cyclic 3', 5'-monophosphate accumulation in control and desensitized C-6 astrocytoma cells.

Authors:  A H Drummond; B C Baguley; M Staehelin
Journal:  Mol Pharmacol       Date:  1977-11       Impact factor: 4.436

4.  A model of desensitization in intact cells.

Authors:  R Barber; R B Clark; L A Kelly; R W Butcher
Journal:  Adv Cyclic Nucleotide Res       Date:  1978

Review 5.  Involvement of cyclic amp and protein synthesis in catecholamine refractoriness.

Authors:  W L Terasaki; G Brooker; J de Vellis; D Inglish; C Y Hsu; R D Moylan
Journal:  Adv Cyclic Nucleotide Res       Date:  1978

6.  The influence of chemical agents on the accumulation of adenosine 3',5'-Phosphate in slices of rabbit cerebellum.

Authors:  S Kakiuchi; T W Rall
Journal:  Mol Pharmacol       Date:  1968-07       Impact factor: 4.436

7.  Gonadotropin action in isolated ovarian luteal cells. The intermediate role of adenosine 3':5'-monophosphate in hormonal stimulation of progesterone synthesis.

Authors:  G B Sala; M L Dufau; K J Catt
Journal:  J Biol Chem       Date:  1979-03-25       Impact factor: 5.157

8.  Desensitization of adenylate cyclase in cultured fibroblasts with prostaglandin E1 and epinephrine.

Authors:  R B Clark; R W Butcher
Journal:  J Biol Chem       Date:  1979-10-10       Impact factor: 5.157

9.  Regulation of adenosine 3':5'-monophosphate content of human astrocytoma cells: mechanism of agonist-specific desensitization.

Authors:  Y F Su; G L Johnson; L Cubeddu; B H Leichtling; R Ortmann; J P Perkins
Journal:  J Cyclic Nucleotide Res       Date:  1976 Jul-AUG
  9 in total
  1 in total

1.  Simulations of the roles of multiple cyclic nucleotide phosphodiesterases.

Authors:  C H Reynolds
Journal:  Biochem J       Date:  1982-01-15       Impact factor: 3.857
  1 in total

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