| Literature DB >> 6250217 |
N H Kalin, S C Risch, R M Cohen, T Insel, D L Murphy.
Abstract
In humans and rhesus monkeys, dexamethasone decreased concentrations of plasma cortisol but did not alter circulating beta-endorphin immunoreactivity. Contrary to current theory suggesting that pituitary beta-endorphin and adrenocorticotropic hormone are controlled by identical regulatory mechanisms for synthesis and release, our evidence suggests that in higher primates the established glucocorticoid feedback mechanism for the adrenocorticotropic hormone-cortisol system does not regulate beta-endorphin secretion in the same way.Entities:
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Year: 1980 PMID： 6250217 DOI： 10.1126/science.6250217
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728