Literature DB >> 6250084

Sodium ions increase the affinity of clonidine for alpha 1-adrenoceptors in rat brain.

H Glossman, R Hornung.   

Abstract

alpha 1-Adrenoceptors in rat brain membranes, labeled by the antagonist [3H] prazosin, increase their affinity for clonidine several-fold when sodium ions are added. The conversion of alpha 1-adrenoceptors, buy sodium ion, into a conformation, which has higher affinity for the agonist clonidine, indicates that these receptors as the alpha 2-adrenoceptors are modulated by cations in vitro.

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Year:  1980        PMID： 6250084     DOI： 10.1007/bf00569717

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  3 in total

1.  Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled alpha adrenergic receptors in rabbit platelets.

Authors:  B S Tsai; R J Lefkowitz
Journal:  Mol Pharmacol       Date:  1978-07       Impact factor: 4.436

2.  Alpha noradrenergic receptors in brain membranes: sodium, magnesium and guanyl nucleotides modulate agonist binding.

Authors:  H Glossmann; P Presek
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-01       Impact factor: 3.000

3.  Alpha adrenoceptors in rat brain: direct identification with prazosin.

Authors:  R Hornung; P Presek; H Glossmann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-09       Impact factor: 3.000
  3 in total
  3 in total

1.  Alpha 2 adrenoceptors in rat brain: the divalent cation site.

Authors:  H Glossmann; R Hornung
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-11       Impact factor: 3.000

2.  Studies on the antinociceptive action of alpha-agonist drugs and their interactions with opioid mechanisms.

Authors:  G A Bentley; S H Newton; J Starr
Journal:  Br J Pharmacol       Date:  1983-05       Impact factor: 8.739

3.  Chlorpromazine hyperalgesia antagonizes clonidine analgesia, but enhances morphine analgesia in rats tested in a hot-water tail-flick paradigm.

Authors:  R M Gleeson; D M Atrens
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530
  3 in total

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