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Literature DB >> 6249891

Sensitivity of viruses to phosphorylated 9-(2-hydroxyethoxymethyl)guanine revealed in TK-transformed cells.

G Darby, B A Larder, K F Bastow, H J Field.

Abstract

Vaccinia and pseudorabies viruses are resistant to ACV [Acyclovir or 9-(2-hydroxyethoxymethyl)guanine] in normal cells. However, both viruses are sensitive in thymidine kinase (TK)-transformed cells in which the resident HSV-specific TK is able to phosphorylate the drug. This demonstrates the sensitivity of these viruses to phosphorylated ACV and suggests a wider antiviral activity for the phosphorylated drug.

Entities: Chemical

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Year: 1980 PMID： 6249891 DOI： 10.1099/0022-1317-48-2-451

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

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Cited

8 in total

1. Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.

Authors: J S Gibbs; H C Chiou; K F Bastow; Y C Cheng; D M Coen
Journal: Proc Natl Acad Sci U S A Date: 1988-09 Impact factor: 11.205

2. The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production.

Authors: Qiao Meng; Stacy R Hagemeier; Joyce D Fingeroth; Edward Gershburg; Joseph S Pagano; Shannon C Kenney
Journal: J Virol Date: 2010-02-24 Impact factor: 5.103

3. Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.

Authors: Mark N Prichard; Kathy A Keith; Mary P Johnson; Emma A Harden; Alexis McBrayer; Ming Luo; Shihong Qiu; Debasish Chattopadhyay; Xuesen Fan; Paul F Torrence; Earl R Kern
Journal: Antimicrob Agents Chemother Date: 2007-02-26 Impact factor: 5.191

Sensitivity of viruses to phosphorylated 9-(2-hydroxyethoxymethyl)guanine revealed in TK-transformed cells.

1. Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.

2. The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production.

3. Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.

4. Cooperative effects between two acyclovir resistance loci in herpes simplex virus.

Review 5. A review of antiviral drugs and other compounds with activity against feline herpesvirus type 1.

6. Development of clinical resistance to acyclovir in herpes simplex virus-infected mice receiving oral therapy.

7. Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus.

8. Herpes Infections and Dementia: Rebutting Alternative Fact.