Literature DB >> 6249765

Activated T lymphocytes in infiltrates and draining lymph nodes of nasopharyngeal carcinoma.

U Galili, E Klein, G Klein, I Singh Bal.   

Abstract

Lymphocytes isolated from the tumors and draining lymph nodes of nasopharyngeal carcinoma (NPC) patients exhibit the following characteristics of immune activation: (1) stable E rosette formation, (2) natural attachment to various human cells, (3) sensitivity in vitro to the lytic effect of glucocorticoids. Although the NPC T cells attach in vitro to various cells they kill only EBV-genome-carrying targets. These findings suggest the occurrence of a local cellular immune response in NPC, possibly directed to EBV-determined antigens.

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Year:  1980        PMID： 6249765     DOI： 10.1002/ijc.2910250111

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  4 in total

1.  Expression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma. Evidence for a functional interaction between epithelial tumor cells and infiltrating lymphoid cells.

Authors:  A Agathanggelou; G Niedobitek; R Chen; J Nicholls; W Yin; L S Young
Journal:  Am J Pathol       Date:  1995-10       Impact factor: 4.307

2.  Thermostable erythrocyte rosette-forming lymphocytes in hereditary hemochromatosis. I. Identification in peripheral blood.

Authors:  C F Bryan; S H Leech; R Ducos; C Q Edwards; J P Kushner; M H Skolnick; B Bozelka; J C Linn; R Gaumer
Journal:  J Clin Immunol       Date:  1984-03       Impact factor: 8.317

3.  Proliferative patterns of lymphocytes in lymph nodes during tumour development: involvement of T and B cell areas.

Authors:  M Bertschmann; R Markwalder-Hartenbach; E Pedrinis; M W Hess; H Cottier
Journal:  Br J Cancer       Date:  1984-04       Impact factor: 7.640

4.  Lymphocyte subsets in tumour of patients with undifferentiated nasopharyngeal carcinoma: presence of lymphocytes with the phenotype of activated T cells.

Authors:  P Herait; G Ganem; M Lipinski; C Carlu; C Micheau; G Schwaab; G De-The; T Tursz
Journal:  Br J Cancer       Date:  1987-02       Impact factor: 7.640
  4 in total

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