Literature DB >> 6249333

Pharmacology of guanfacine.

G Scholtysik.   

Abstract

1. The pharmacological effects of the centrally acting antihypertensive drug guanfacine are reviewed. 2. The drug lowers systemic blood pressure in hypertensive rats dose-dependently after oral application of 0.3-5 mg/kg. 3. Evidence is presented that guanfacine produces its antihypertensive action by a specific stimulation of central alpha-adrenoceptors. 4. Certain pharmacological differences between clonidine and guanfacine are discussed.

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Year:  1980        PMID： 6249333      PMCID： PMC1430122          DOI： 10.1111/j.1365-2125.1980.tb04900.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  16 in total

1.  Inhibitory effects of clonidine and BS 100-141 on responses to sympathetic nerve stimulation in cats and rabbits.

Authors:  W Pacha; R Salzmann; G Scholtysik
Journal:  Br J Pharmacol       Date:  1975-04       Impact factor: 8.739

2.  Effects of clonidine and BS 100-141 on the EEG sleep pattern in rats.

Authors:  H Kleinlogel; G Scholtysik; A C Sayers
Journal:  Eur J Pharmacol       Date:  1975-08       Impact factor: 4.432

3.  Noradrenaline: central inhibitory control of blood pressure and heart rate.

Authors:  W De Jong
Journal:  Eur J Pharmacol       Date:  1974-11       Impact factor: 4.432

4.  Central alpha- and beta-adrenoceptors modifying arterial blood pressure and heart rate in conscious cats.

Authors:  M D Day; A G Roach
Journal:  Br J Pharmacol       Date:  1974-07       Impact factor: 8.739

5.  The effect of clonidine on adrenergic nerve function in vagotomized and nonvagotomized animals.

Authors:  M J Antonaccio; R D Robson
Journal:  J Pharmacol Exp Ther       Date:  1973-03       Impact factor: 4.030

6.  Inhibition by sympathomimetic amines of the release of norepinephrine evoked by nerve stimulation in the cat spleen.

Authors:  S M Kirpekar; R F Furchgott; A R Wakade; J C Prat
Journal:  J Pharmacol Exp Ther       Date:  1973-12       Impact factor: 4.030

7.  Localization of the central cardiovascular action of clonidine.

Authors:  P Bousquet; P G Guertzenstein
Journal:  Br J Pharmacol       Date:  1973-12       Impact factor: 8.739

8.  Inhibition of adrenergic neurotransmission by clonidine: an action on prejunctional -receptors.

Authors:  K Starke; K P Altmann
Journal:  Neuropharmacology       Date:  1973-04       Impact factor: 5.250

9.  Action of clonidine on baroreceptor reflexes in conscious dogs.

Authors:  A Walland; W Kobinger; A Csongrady
Journal:  Eur J Pharmacol       Date:  1974-05       Impact factor: 4.432

10.  Centrally mediated decrease in sympathetic tone induced by 2(2,6-dichlorophenylamino)-2 imidazoline (S.T. 155, Catapresan).

Authors:  H Schmitt; J R Boissier; J F Giudicelli
Journal:  Eur J Pharmacol       Date:  1967-11       Impact factor: 4.432
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  7 in total

1.  Effects of guanabenz and guanfacine on postsynaptic alpha 2-adrenoceptors in the rat submaxillary and parotid glands.

Authors:  M D Kaniucki; J C Elverdin; F J Stefano; C J Perec
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-05       Impact factor: 3.000

2.  Sources of calcium used during alpha 1- and alpha 2-adrenergic contractions in canine saphenous veins.

Authors:  W Janssens; R Verhaeghe
Journal:  J Physiol       Date:  1984-02       Impact factor: 5.182

3.  Effects of alpha 2-adrenoceptor agonists on locus coeruleus firing rate and brain noradrenaline turnover in N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)-treated rats.

Authors:  G Engberg; E Eriksson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-05       Impact factor: 3.000

4.  Guanfacine and clonidine: antihypertensive and withdrawal characteristics after continuous infusion and its interruption in the spontaneously hypertensive and normotensive rat.

Authors:  M J Thoolen; P B Timmermans; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-04       Impact factor: 3.000

5.  Effects of calcium channel blockade in canine saphenous veins after storage at -190 degrees C.

Authors:  A B Ebeigbe; E Müller-Schweinitzer; A Vogel
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739

6.  Noradrenergic circuits in the forebrain control affective responses to novelty.

Authors:  Daniel Lustberg; Rachel P Tillage; Yu Bai; Molly Pruitt; L Cameron Liles; David Weinshenker
Journal:  Psychopharmacology (Berl)       Date:  2020-07-28       Impact factor: 4.530

7.  Central norepinephrine transmission is required for stress-induced repetitive behavior in two rodent models of obsessive-compulsive disorder.

Authors:  Daniel Lustberg; Alexa F Iannitelli; Rachel P Tillage; Molly Pruitt; L Cameron Liles; David Weinshenker
Journal:  Psychopharmacology (Berl)       Date:  2020-04-20       Impact factor: 4.530
  7 in total

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