Literature DB >> 6249238

Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein.

M Younes, C P Siegers.   

Abstract

Dithiocarb and (+)-cyanidanol-3-prevented paracetamol-induced liver injury in rats in vivo. Both, as well as two other antihepatotoxic agents, deanol and DMSO, inhibited covalent binding of [3H]-paracetamol to rat liver microsomal proteins in vitro. Dithiocarb and (+)-cyanidanol-3 were the most effective inhibitors. The concentrations of the antidotes yielding 50% inhibition (I50) valued 1 . 8 x 10(-5) M for dithiocarb and 2 . 1 x 10(-5) M for (+)-cyanidanol-3.

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Year:  1980        PMID： 6249238     DOI： 10.1007/bf00303296

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  14 in total

1.  Effect of dithiocarb on metabolism and covalent binding of carbon tetrachloride.

Authors:  C P Siegers; J G Filser; H M Bolt
Journal:  Toxicol Appl Pharmacol       Date:  1978-12       Impact factor: 4.219

2.  The antihepatotoxic activity of dithiocarb as compared with six other thio compounds in mice.

Authors:  C P Siegers; O Strubelt; M Völpel
Journal:  Arch Toxicol       Date:  1978-10-13       Impact factor: 5.153

3.  Antidotal effects of dimethyl sulphoxide against paracetamol-, bromobenzene-, and thioacetamide-induced hepatotoxicity.

Authors:  C P Siegers
Journal:  J Pharm Pharmacol       Date:  1978-06       Impact factor: 3.765

4.  Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

Authors:  D J Jollow; J R Mitchell; W Z Potter; D C Davis; J R Gillette; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1973-10       Impact factor: 4.030

5.  Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

Authors:  J R Mitchell; D J Jollow; W Z Potter; D C Davis; J R Gillette; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1973-10       Impact factor: 4.030

6.  An in vitro model of liver injury using paracetamol treatment of liver slices and prevention of injury by some antioxidants.

Authors:  A E McLean; L Nutiall
Journal:  Biochem Pharmacol       Date:  1978-02-15       Impact factor: 5.858

7.  Irreversible protein binding of metabolites of ethynylestradiol in vivo and in vitro.

Authors:  H Kappus; H M Bolt; H Remmer
Journal:  Steroids       Date:  1973-08       Impact factor: 2.668

8.  Renal necrosis, glutathione depletion, and covalent binding after acetaminophen.

Authors:  R J McMurtry; W R Snodgrass; J R Mitchell
Journal:  Toxicol Appl Pharmacol       Date:  1978-10       Impact factor: 4.219

9.  Effect of dithiocarb and dimethyl sulfoxide on irreversible binding of 14C-bromobenzene to rat liver microsomal protein.

Authors:  M Younes; C P Siegers; J G Filser
Journal:  Arch Toxicol       Date:  1979-09       Impact factor: 5.153

10.  [Influence of 2-dimethylaminoethanol on the hepatotoxicity of paracetamol in rats and mice (author's transl)].

Authors:  C P Siegers; M Younes
Journal:  Arzneimittelforschung       Date:  1979
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  3 in total

1.  Effect of diethyldithiocarbamate (DDC) on human monocyte function and metabolism.

Authors:  P Conkling; D G Cornwell; A L Sagone
Journal:  Inflammation       Date:  1985-06       Impact factor: 4.092

2.  The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.

Authors:  Melissa M Clemens; Stefanie Kennon-McGill; Udayan Apte; Laura P James; Brian N Finck; Mitchell R McGill
Journal:  Food Chem Toxicol       Date:  2019-01-14       Impact factor: 6.023

3.  Effects of dithiocarb and (+)-catechin against carbon tetrachloride-alcohol-induced liver fibrosis.

Authors:  C P Siegers; M Völpel; G Scheel; M Younes
Journal:  Agents Actions       Date:  1982-12
  3 in total

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