Literature DB >> 6249237

Effects of diethyldithiocarbamate and penicillamine on the tissue distribution of 63NiCl2 in mice.

A Oskarsson, H Tjälve.   

Abstract

The effects of sodium diethyldithiocarbamate and DL-penicillamine on the fate of 63Ni2+ in mice injected with 63NiCl2 were studied by whole body autoradiography and liquid scintillation counting. Sodium diethyldithiocarbamate caused a retention and redistribution of 63Ni2+ in the tissues. DL-penicillamine decreased the 63Ni2+-concentration in the tissues. The nickel-diethyldithiocarbamate complex is lipophilic, whereas the nickel-DL-penicillamine complex is hydrophilic, and these differences in chemical properties may determine the different effects which these chelating agents have on the fate of Ni2+.

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Year:  1980        PMID： 6249237     DOI： 10.1007/bf00303294

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  9 in total

1.  Studies on the distribution and fate of S35-labelled benzylpenicillin in the body.

Authors:  S ULLBERG
Journal:  Acta Radiol Suppl       Date:  1954

2.  Comparisons of antidotal efficacy of sodium diethyldithiocarbamate, D-penicillamine and triethylenetetramine upon acute toxicity of nickel carbonyl in rats.

Authors:  R C Baselt; F W Sunderman; J Mitchell; E Horak
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1977-12

3.  Effects of triethylenetetramine upon the metabolism and toxicity of 63NiCl2 in rats.

Authors:  F W Sunderman; K Kasprzak; E Horak; P Gitlitz; C Onkelinx
Journal:  Toxicol Appl Pharmacol       Date:  1976-10       Impact factor: 4.219

4.  Efficacy of sodium diethyldithiocarbamate (dithiocarb) in acute nickel carbonyl poisoning.

Authors:  F W Sunderman
Journal:  Ann Clin Lab Sci       Date:  1979 Jan-Feb       Impact factor: 1.256

5.  Dithiocarbamate therapy for nickel dermatitis.

Authors:  D Spruit; P J Bongaarts; G J de Jongh
Journal:  Contact Dermatitis       Date:  1978-12       Impact factor: 6.600

6.  The distribution and metabolism of nickel carbonyl in mice.

Authors:  A Oskarsson; H Tjälve
Journal:  Br J Ind Med       Date:  1979-11

7.  Nickel poisoning. VII. The therapeutic effectiveness of alkyl dithiocarbamates in experimental animals exposed to nickel carbonyl.

Authors:  B WEST; F W SUNDERMAN
Journal:  Am J Med Sci       Date:  1958-07       Impact factor: 2.378

8.  An autoradiographic study on the distribution of 63NiCl2 in mice.

Authors:  A Oskarsson; H Tjälve
Journal:  Ann Clin Lab Sci       Date:  1979 Jan-Feb       Impact factor: 1.256

9.  Comparisons of antidotal efficacy of chelating drugs upon acute toxicity of Ni(II) in rats.

Authors:  E Horak; F W Sunderman; B Sarkar
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1976-05
  9 in total
  4 in total

1.  Influence of a prolonged treatment with disulfiram and D-penicillamine on nitrosodiethylamine-induced biological and biochemical effects. II. Investigations on trace elements in the liver.

Authors:  J Schuhmacher; H R Scherf; B Bertram; E Frei; H Hauser; M Wiessler
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553

2.  Effects of some chelating agents on the uptake and distribution of 203Hg2+ in the brown trout (Salmo trutta): studies on ethyl- and isopropylxanthate, diethyl- and diisopropyldithiophosphate, dimethyl- and diethyldithiocarbamate and pyridinethione.

Authors:  K Borg; J Gottofrey; H Tjälve
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

3.  Ozone and ozone/vacuum-UV degradation of diethyl dithiocarbamate collector: kinetics, mineralization, byproducts and pathways.

Authors:  Pingfeng Fu; Yanhong Ma; Huifen Yang; Gen Li; Xiaofeng Lin
Journal:  RSC Adv       Date:  2019-07-30       Impact factor: 4.036

4.  Erythropoietin-mediated erythrocytosis in rodents after intrarenal injection of nickel subsulfide.

Authors:  F W Sunderman; S M Hopfer; M C Reid; S K Shen; C B Kevorkian
Journal:  Yale J Biol Med       Date:  1982 Mar-Apr
  4 in total

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