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Literature DB >> 6247616

Serine sensitivity of Escherichia coli K 12: partial characterization of a serine resistnat mutant that is extremely sensitive to 2-ketobutyrate.

Abstract

E. coli wild type bacteria display sensitivity towards serine. A selection medium is described which allows selection of serine resistant mutants. One such mutant is described which presents pleiotropic alterations: it exhibits a thermosensitive growth pattern, alteration in the metabolism of the pppGpp and ppGpp nucleotides, cAMP intracellular level alteration, extreme sensitivity to 2-ketobutyric acid and a defect in the phosphotransferases permeation system. A conjecture explaining these apparently unrelated defects supposes that serine metabolism interferes via phosphoenol pyruvate with a cytoplasmic control of membrane activity (the mutant would be defective in the coupling between membrane and the protein responsible for its cytoplasmic control) and that 2-ketobutyrate is an effector of this activity.

Entities: Chemical Species

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Year: 1980 PMID： 6247616 DOI： 10.1007/bf00267224

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

26 in total

1. NEUTRALIZATION OF THE AMINO ACID SENSITIVITY OF RCREL ESCHERICHIA COLI.

Authors: L ALFOELDI; E KEREKES
Journal: Biochim Biophys Acta Date: 1964-09-11

2. Coordinate regulation of adenylate cyclase and carbohydrate permeases by the phosphoenolpyruvate:sugar phosphotransferase system in Salmonella typhimurium.

Authors: M H Saier; B U Feucht
Journal: J Biol Chem Date: 1975-09-10 Impact factor: 5.157

3. A rapid test for the rel A mutation in E. coli.

Authors: M Uzan; A Danchin
Journal: Biochem Biophys Res Commun Date: 1976-04-05 Impact factor: 3.575

4. Energy coupling to net K+ transport in Escherichia coli K-12.

Authors: D B Rhoads; W Epstein
Journal: J Biol Chem Date: 1977-02-25 Impact factor: 5.157

5. A consequence of the rel gene during a glucose to lactate downshift in Escherichia coli. The rates of ribonucleic acid synthesis.

Authors: R M Winslow
Journal: J Biol Chem Date: 1971-08-10 Impact factor: 5.157

6. A colony bank containing synthetic Col El hybrid plasmids representative of the entire E. coli genome.

Authors: L Clarke; J Carbon
Journal: Cell Date: 1976-09 Impact factor: 41.582

7. Mutants of Escherichia coli defective in the degradation of guanosine 5'-triphosphate, 3'-diphosphate (pppGpp).

Authors: C R Somerville; A Ahmed
Journal: Mol Gen Genet Date: 1979-02-01

8. Involvement of the relA gene product and feedback inhibition in the regulation of DUP-N-acetylmuramyl-peptide synthesis in Escherichia coli.

Authors: E E Ishiguro; W D Ramey
Journal: J Bacteriol Date: 1978-09 Impact factor: 3.490

2. Complex metabolic phenotypes caused by a mutation in yjgF, encoding a member of the highly conserved YER057c/YjgF family of proteins.

Authors: J L Enos-Berlage; M J Langendorf; D M Downs
Journal: J Bacteriol Date: 1998-12 Impact factor: 3.490

10. A new pleiotropic mutation causing defective carbohydrate uptake in Escherichia coli K-12: isolation, mapping, and preliminary characterization.

Authors: S K Mahajan; N B Vartak; A R Datta
Journal: J Bacteriol Date: 1988-06 Impact factor: 3.490

Serine sensitivity of Escherichia coli K 12: partial characterization of a serine resistnat mutant that is extremely sensitive to 2-ketobutyrate.

1. NEUTRALIZATION OF THE AMINO ACID SENSITIVITY OF RCREL ESCHERICHIA COLI.

2. Coordinate regulation of adenylate cyclase and carbohydrate permeases by the phosphoenolpyruvate:sugar phosphotransferase system in Salmonella typhimurium.

3. A rapid test for the rel A mutation in E. coli.

4. Energy coupling to net K+ transport in Escherichia coli K-12.

5. A consequence of the rel gene during a glucose to lactate downshift in Escherichia coli. The rates of ribonucleic acid synthesis.

6. A colony bank containing synthetic Col El hybrid plasmids representative of the entire E. coli genome.

7. Mutants of Escherichia coli defective in the degradation of guanosine 5'-triphosphate, 3'-diphosphate (pppGpp).

8. Involvement of the relA gene product and feedback inhibition in the regulation of DUP-N-acetylmuramyl-peptide synthesis in Escherichia coli.

9. Rapid mapping of conditional and auxotrophic mutations in Escherichia coli K-12.

10. Cluster of ribosomal protein genes in Escherichia coli containing genes for proteins S6, S18, and L9.

Review 1. Linkage map of Escherichia coli K-12, edition 10: the traditional map.

2. Complex metabolic phenotypes caused by a mutation in yjgF, encoding a member of the highly conserved YER057c/YjgF family of proteins.

3. Metabolic alterations mediated by 2-ketobutyrate in Escherichia coli K12.

Review 4. Linkage map of Escherichia coli K-12, edition 7.

5. Identification of the protein products of the rrnC, ilv, rho region of the Escherichia coli K-12 chromosome.

Review 6. Gene-protein index of Escherichia coli K-12.

Review 7. Functions of the gene products of Escherichia coli.

8. A new gene in E. coli RNA synthesis.

9. Elevated serine catabolism is associated with the heat shock response in Escherichia coli.

10. A new pleiotropic mutation causing defective carbohydrate uptake in Escherichia coli K-12: isolation, mapping, and preliminary characterization.