| Literature DB >> 6247489 |
J H Wikel, C J Paget, D C DeLong, J D Nelson, C Y Wu, J W Paschal, A Dinner, R J Templeton, M O Chaney, N D Jones, J W Chamberlin.
Abstract
The synthesis and antirhinovirus activity of syn and anti isomers of 6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine (4 and 5) are reported. The structural assignments of 4 and 5 are based upon 13C NMR spectra of both isomers and also X-ray analysis of 5. The anti-isomer 5 was more potent than the syn-isomer 4 when compared as an inhibitor of rhinovirus multiplication in vitro. Both isomers inhibited multiplication of 15 different serotypes of rhinovirus.Entities:
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Year: 1980 PMID： 6247489 DOI： 10.1021/jm00178a004
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446