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Literature DB >> 6246530

Highly efficient induction of type C retroviruses by a human tumor in athymic mice.

J W Gautsch, A F Knowles, F C Jensen, N O Kaplan.

Abstract

We have found that 1 of 20 human tumors transplanted and passaged in nude mice was associated with a massive induction of endogenous murine leukemia virus (MuLV). Separation and growth of these viruses on various substrates indicated that both ecotropic and xenotropic MuLV were present in the induced mixture. Tryptic peptide fingerprints of the p30 and gp70 structural elements of the viruses indicated that all of the known endogenous muLVs of BALB/c mice were present in the mixture. In addition, a new xenotropic MuLV was identified. The human tumor that induced the viruses was an oat cell carcinoma. The oat cell carcinoma possibly produced a specific hormone or factor that acts as a potent inducer of endogenous type C retroviruses.

Entities: Chemical

Mesh：

Substances：
Viral Proteins

Year: 1980 PMID： 6246530 PMCID： PMC348690 DOI： 10.1073/pnas.77.4.2247

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 12.779

12 in total

1. Serological characterization of B-tropic viruses of C57BL mice: possible origin by recombination of endogenous N-tropic and xenotropic viruses.

Authors: L E Benade; J N Ihle; A Declève
Journal: Proc Natl Acad Sci U S A Date: 1978-09 Impact factor: 11.205

2. Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein.

Authors: J H Elder; R A Pickett; J Hampton; R A Lerner
Journal: J Biol Chem Date: 1977-09-25 Impact factor: 5.157

3. A short-term quantitative XC assay for murine leukemia virus.

Authors: J W Gautsch; H Meier
Journal: Virology Date: 1976-07-15 Impact factor: 3.616

4. Identification of murine endogenous xenotropic retrovirus in cultured multicellular tumour spheroids from nude-mouse-passaged nasopharyngeal carcinoma.

Authors: D H Crawford; B G Achong; N M Teich; S Finerty; J L Thompson; M A Epstein; B C Giovanella
Journal: Int J Cancer Date: 1979-01-15 Impact factor: 7.396

5. Structural markers on core protein p30 of murine leukemia virus: functional correlation with Fv-1 tropism.

Authors: J W Gautsch; J H Elder; J Schindler; F C Jensen; R A Lerner
Journal: Proc Natl Acad Sci U S A Date: 1978-09 Impact factor: 11.205

6. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

7. Plaque assay techniques for murine leukemia viruses.

Authors: W P Rowe; W E Pugh; J W Hartley
Journal: Virology Date: 1970-12 Impact factor: 3.616

8. Infectious murine type-C viruses released from human cancer cells transplated into nude mice.

Authors: T Suzuki; K Yanagihara; K Yoshida; T Seido; N Kuga
Journal: Gan Date: 1977-02

9. Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures.

Authors: J W Hartley; W P Rowe; R J Huebner
Journal: J Virol Date: 1970-02 Impact factor: 5.103

10. C-type virus particles in human urogenital tumours after heterotransplantation into nude mice.

Authors: H Wunderli; D D Mickey; D F Paulson
Journal: Br J Cancer Date: 1979-01 Impact factor: 9.075

12 in total

Review 1. Lung cancer cell lines as tools for biomedical discovery and research.

Authors: Adi F Gazdar; Luc Girard; William W Lockwood; Wan L Lam; John D Minna
Journal: J Natl Cancer Inst Date: 2010-08-02 Impact factor: 13.506

2. Induction of lymphoma in athymic mice: a model for study of the human disease.

Authors: G Beattie; S Baird; R Lannom; S Slimmer; F C Jensen; N O Kaplan
Journal: Proc Natl Acad Sci U S A Date: 1980-08 Impact factor: 11.205

3. Induction of sarcomas in athymic mice.

Authors: G M Beattie; A F Knowles; F C Jensen; S M Baird; N O Kaplan
Journal: Proc Natl Acad Sci U S A Date: 1982-05 Impact factor: 11.205

4. Envelope and long terminal repeat sequences of an infectious murine leukemia virus from a human SCLC cell line: implications for gene transfer.

Authors: M Antoine; B Wegmann; P Kiefer
Journal: Virus Genes Date: 1998 Impact factor: 2.332

5. A retrovirus-producing transformed mouse cell line derived from a human breast adenocarcinoma transplanted in a nude mouse.

Authors: J M Bowen; R Cailleau; B C Giovanella; S Pathak; M J Siciliano
Journal: In Vitro Date: 1983-08

6. Susceptibility of human lymphoid tissue cultured ex vivo to xenotropic murine leukemia virus-related virus (XMRV) infection.

Authors: Marta Curriu; Jorge Carrillo; Marta Massanella; Elisabet Garcia; Francesc Cunyat; Ruth Peña; Peter Wienberg; Cristina Carrato; Joan Areal; Margarita Bofill; Bonaventura Clotet; Julià Blanco; Cecilia Cabrera
Journal: PLoS One Date: 2012-05-16 Impact factor: 3.752

7. Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts.

Authors: Yu-An Zhang; Anirban Maitra; Jer-Tsong Hsieh; Charles M Rudin; Craig D Peacock; Collins Karikari; Rolf A Brekken; Victor Stastny; Boning Gao; Luc Girard; Ignacio Wistuba; Eugene Frenkel; John D Minna; Adi F Gazdar
Journal: Cancer Biol Ther Date: 2011-10-01 Impact factor: 4.875