Literature DB >> 6245773

The variability, arrangement, and rearrangement of immunoglobulin genes.

T H Rabbitts, P H Hamlyn, G Matthyssens, B A Roe.   

Abstract

The multiplicity of heavy-chain variable-region (VH) genes in mouse and human DNA has been estimated using a mouse heavy-(H) chain cDNA clone. We found about 10 hybridization components in mouse DNA and about 20 components in human DNA. Cross-hybridization studies of variable region (V) genes indicate that these components represent the numbers of genes within the VH subgroups of each of these species. The arrangement and rearrangement of the H-chain gamma subclasses have been studied in order to assess possible mechanisms of the H-chain switch. Evidence has been found for rearrangement events involving the gamma 2a and gamma 2b constant-region (CH) genes in DNA from cells making IgG2a and IgG2b respectively. In addition we found that cells making IgG2a lack detectable genes for gamma1 and gamma 2b. Both sets of observations are discussed in relation to H-chain diversity and the switch.

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Year:  1980        PMID： 6245773     DOI： 10.1139/o80-024

Source DB:  PubMed          Journal:  Can J Biochem        ISSN： 0008-4018


  6 in total

1.  Immunoglobulin gene rearrangements and deletions in human Epstein-Barr virus-transformed cell lines producing different IgG and IgA subclasses.

Authors:  C F Webb; M D Cooper; P D Burrows; J A Griffin
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

2.  The immunoglobulin heavy chain class switch.

Authors:  P D Burrows; M D Cooper
Journal:  Mol Cell Biochem       Date:  1984-09       Impact factor: 3.396

3.  Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences.

Authors:  T H Rabbitts; A Forster; C P Milstein
Journal:  Nucleic Acids Res       Date:  1981-09-25       Impact factor: 16.971

4.  Preferential rearrangement of the immunoglobulin kappa chain joining region J kappa 1 and J kappa 2 segments in mouse spleen DNA.

Authors:  M Nishi; T Kataoka; T Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

5.  The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.

Authors:  J G Flanagan; T H Rabbitts
Journal:  EMBO J       Date:  1982       Impact factor: 11.598

6.  Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes.

Authors:  U Krawinkel; T H Rabbitts
Journal:  EMBO J       Date:  1982       Impact factor: 11.598
  6 in total

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