Literature DB >> 6244238

Inhibition of cytomegalovirus late antigens by phosphonoformate.

B Wahren, B Oberg.   

Abstract

Phosphonoformate (PFA) at a concentration of 500 muM and higher completely inhibited the replication of cytomegalovirus (CMV) in cell culture. 50% inhibition was obtained at a concentration of muM PFA. Early nuclear CMV antigens appeared uninhibited, but the formation of nuclear inclusion bodies, late cytoplasmic antigens, Fc-receptors and CPE were all inhibited by PFA. No visible cell toxicity was noted at the PFA concentrations and exposure times used.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6244238     DOI： 10.1159/000149093

Source DB:  PubMed          Journal:  Intervirology        ISSN： 0300-5526            Impact factor:   1.763


  21 in total

1.  Global analysis of host cell gene expression late during cytomegalovirus infection reveals extensive dysregulation of cell cycle gene expression and induction of Pseudomitosis independent of US28 function.

Authors:  Laura Hertel; Edward S Mocarski
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

2.  Cytomegalovirus early and late membrane antigens detected by antibodies in human convalescent sera.

Authors:  J M Middeldorp; J Jongsma; T H The
Journal:  J Virol       Date:  1985-04       Impact factor: 5.103

3.  Activity of the cytomegalovirus genome in the presence of PPi analogs.

Authors:  B Wahren; U Rudén; H Gadler; B Oberg; B Eriksson
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

4.  Identification and characterization of a major early cytomegalovirus DNA-binding protein.

Authors:  D G Anders; A Irmiere; W Gibson
Journal:  J Virol       Date:  1986-05       Impact factor: 5.103

5.  Monocyte and iscom enhancement of cell-mediated response to cytomegalovirus.

Authors:  B Wahren; S Nordlund; A Akesson; V A Sundqvist; B Morein
Journal:  Med Microbiol Immunol       Date:  1987       Impact factor: 3.402

6.  Location, transcript analysis, and partial nucleotide sequence of the cytomegalovirus gene encoding an early DNA-binding protein with similarities to ICP8 of herpes simplex virus type 1.

Authors:  D G Anders; W Gibson
Journal:  J Virol       Date:  1988-04       Impact factor: 5.103

7.  Detection of immunoglobulin M and G antibodies against cytomegalovirus early and late antigens by enzyme-linked immunosorbent assay.

Authors:  J M Middeldorp; J Jongsma; A ter Haar; J Schirm; T H The
Journal:  J Clin Microbiol       Date:  1984-10       Impact factor: 5.948

8.  Early interactions between human cytomegalovirus and cells.

Authors:  B Wahren; L Einhorn; H Gadler
Journal:  Arch Virol       Date:  1984       Impact factor: 2.574

9.  An inducible promoter mediates abundant expression from the immediate-early 2 gene region of human cytomegalovirus at late times after infection.

Authors:  E Puchtler; T Stamminger
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

10.  Effects of antiviral agents on murine cytomegalovirus-induced macrophage dysfunction.

Authors:  J D Shanley; E L Pesanti
Journal:  Infect Immun       Date:  1982-06       Impact factor: 3.441
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.