Literature DB >> 6244173

Increase in pituitary melanocyte-stimulating hormone activity of genetically obese (ob/ob) mice.

M H Peaslee, B Moisset, H Shibuya, C B Pert.   

Abstract

Melanocyte-stimulating hormone (MSH) activity was measured in the pituitaries of genetically obese and lean control mice using the frog skin bioassay. Obese mice pituitaries demonstrated very significantly elevated levels of biologically active MSH when compared to their lean littermates. These results support the hypothesis that the elevated levels of pituitary hormones found in obese mice possesses true biological activity.

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Year:  1980        PMID： 6244173     DOI： 10.1007/bf02004019

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  In vitro bioassay for the melanocyte stimulating hormone.

Authors:  K SHIZUME; A B LERNER; T B FITZPATRICK
Journal:  Endocrinology       Date:  1954-05       Impact factor: 4.736

2.  The pituitary-adrenal system of the genetically obese (ob/ob) mouse.

Authors:  J A Edwardson; C A Hough
Journal:  J Endocrinol       Date:  1975-04       Impact factor: 4.286

3.  Pituitary intermediate lobe function in genetically obese (ob/ob) and lean mice [proceedings].

Authors:  S Beevor; A Beloff-Chain; A Donaldson; J A Edwardson
Journal:  J Physiol       Date:  1978-02       Impact factor: 5.182

4.  The influence of genetic background on the expression of the obese (Ob) gene in the mouse.

Authors:  D L Coleman; K P Hummel
Journal:  Diabetologia       Date:  1973-08       Impact factor: 10.122

5.  Pituitary peptide.

Authors:  A P Scott; J G Ratcliffe; L H Rees; J Landon; H P Bennett; P J Lowry; C McMartin
Journal:  Nat New Biol       Date:  1973-07-18

6.  Effect of a phenothiazine tranquillizer on plasma melanophore-stimulating activity in Spanish goats.

Authors:  M H Peaslee; S E Milburn
Journal:  J Endocrinol       Date:  1971-10       Impact factor: 4.286

7.  Common precursor to corticotropins and endorphins.

Authors:  R E Mains; B A Eipper; N Ling
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

8.  beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa).

Authors:  D L Margules; B Moisset; M J Lewis; H Shibuya; C B Pert
Journal:  Science       Date:  1978-12-01       Impact factor: 47.728
  8 in total
  2 in total

1.  Adipocyte versus pituitary leptin in the regulation of pituitary hormones: somatotropes develop normally in the absence of circulating leptin.

Authors:  Angela K Odle; Anessa Haney; Melody Allensworth-James; Noor Akhter; Gwen V Childs
Journal:  Endocrinology       Date:  2014-08-13       Impact factor: 4.736

2.  Age-related changes in adenohypophyses of mice with the hereditary obese hyperglycemic syndrome (ob/ob) in relation to the diabetic state of the animals.

Authors:  W Schouten; B G Jenks; P H Van der Kroon
Journal:  Acta Diabetol Lat       Date:  1982 Jul-Sep
  2 in total

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