Literature DB >> 6243568

Decreased number of beta-adrenoceptors in cerebral cortex of hypothyroid rats.

G Gross, O E Brodde, H J Schümann.   

Abstract

The influence of thyroid hormone deficiency on beta-adrenoceptors in the rat cerebral cortex was investigated using the 3H-dihydroalprenolol binding assay. The maximal number of binding sites (Bmax) and the dissociation constants (KD) were determined in the brain tissue from euthyroid animals and from rats made hypothyroid by feeding 6-propyl-2-thiouracil. Hypothyroidism resulted in a 37% decrease in beta-adrenoceptor density (Bmax). The dissociation constants (KD) of both groups were not significantly different.

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Year:  1980        PMID： 6243568     DOI： 10.1016/0014-2999(80)90164-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

1.  Thyroid hormone and norepinephrine: effects on alpha-2, beta, and reuptake sites in cerebral cortex and heart.

Authors:  A C Swann
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

2.  Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain.

Authors:  C K Atterwill; S J Bunn; D J Atkinson; S L Smith; D J Heal
Journal:  J Neural Transm       Date:  1984       Impact factor: 3.575

3.  Thyroxin dependency of the developing locus coeruleus. Evidence from intraocular grafting experiments.

Authors:  A Seiger; A C Granholm
Journal:  Cell Tissue Res       Date:  1981       Impact factor: 5.249

4.  Effects of hypothyroidism on RNA synthesis in the adult rat brain.

Authors:  N Yiannakouris; T Valcana
Journal:  Neurochem Res       Date:  1994-10       Impact factor: 3.996

5.  Regulation of alpha 1-adrenoceptors in the cerebral cortex of the rat by thyroid hormones.

Authors:  G Gross; O E Brodde; H J Schümann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-02       Impact factor: 3.000
  5 in total

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