Literature DB >> 6241658

Neurotoxic effects of copper: inhibition of glycolysis and glycolytic enzymes.

J C Lai, J P Blass.   

Abstract

The effects of Cu2+ on glycolysis and several glycolytic enzymes were studied in rat brain extracts in vitro. At concentrations reportedly found in Wilson's disease, Cu2+ significantly inhibited lactate production from glucose or glucose-6-phosphate in rat brain postnuclear supernatant with an IC50 of about 3 microM. Cu2+ also inhibited several glycolytic enzymes. Amongst the latter, Cu2+ was most effective in inhibiting hexokinase (IC50 for Cu2+ = 7 microM), moderately effective in inhibiting pyruvate kinase (IC50 for Cu2+ = 56 microM), but least effective in inhibiting lactate dehydrogenase (IC50 for Cu2+ = 300 microM). These results suggest that inhibition of brain glycolysis may have pathophysiological importance in copper poisoning and in Wilson's disease.

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Year:  1984        PMID： 6241658     DOI： 10.1007/bf00968080

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  19 in total

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Authors:  J C Lai; J M Walsh; S C Dennis; J B Clark
Journal:  J Neurochem       Date:  1977-03       Impact factor: 5.372

2.  Studies on the toxicity of copper. II. The behaviour of microsomal membrane ATPase of the pigeon's brain tissue to copper and some other metallic substances.

Authors:  R Peters; M Shorthouse; J M Walshe
Journal:  Proc R Soc Lond B Biol Sci       Date:  1966-12-13

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Authors:  P S Epstein; H McIlwain
Journal:  Proc R Soc Lond B Biol Sci       Date:  1966-12-13

4.  Studies on the interaction of chick brain microsomal (Na+ + K+)-ATPase with copper.

Authors:  H P Ting-Beall; D A Clark; C H Suelter; W W Wells
Journal:  Biochim Biophys Acta       Date:  1973-01-02

5.  Seizures in rats associated with divalent cation inhibition of NA + -K + -ATP'ase.

Authors:  J Donaldson; T St Pierre; J Minnich; A Barbeau
Journal:  Can J Biochem       Date:  1971-11

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Authors:  H K Chuttani; P S Gupta; S Gulati; D N Gupta
Journal:  Am J Med       Date:  1965-11       Impact factor: 4.965

Review 7.  Metals and melanins in the extrapyramidal centers.

Authors:  G Curzon
Journal:  Pharmacol Ther B       Date:  1975

8.  The activity of glucose-6-phosphate dehydrogenase in liver and hypothalamus of the female rat: effects of administration of ethinyloestradiol and the progestogens norethisterone acetate and d-norgestrel.

Authors:  J C Lai; T K Leung; W Marr; L Lim
Journal:  Biochem Soc Trans       Date:  1980-10       Impact factor: 5.407

9.  Progressive lenticular degeneration: a familial nervous disease associated with cirrhosis of the liver, by S. A. Kinnier Wilson, (From the National Hospital, and the Laboratory of the National Hospital, Queen Square, London) Brain 1912: 34; 295-509.

Authors:  Alastair Compston
Journal:  Brain       Date:  2009-08       Impact factor: 13.501

10.  Inhibition of brain glycolysis by aluminum.

Authors:  J C Lai; J P Blass
Journal:  J Neurochem       Date:  1984-02       Impact factor: 5.372
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  7 in total

1.  Uptake and Toxicity of Copper Oxide Nanoparticles in C6 Glioma Cells.

Authors:  Arundhati Joshi; Wiebke Rastedt; Kathrin Faber; Aaron G Schultz; Felix Bulcke; Ralf Dringen
Journal:  Neurochem Res       Date:  2016-08-03       Impact factor: 3.996

2.  Metabolomics profiles of patients with Wilson disease reveal a distinct metabolic signature.

Authors:  Gaurav V Sarode; Kyoungmi Kim; Dorothy A Kieffer; Noreene M Shibata; Tomas Litwin; Anna Czlonkowska; Valentina Medici
Journal:  Metabolomics       Date:  2019-03-12       Impact factor: 4.290

3.  Biochemical effects of copper nanomaterials in human hepatocellular carcinoma (HepG2) cells.

Authors:  Kirk T Kitchin; Judy A Richards; Brian L Robinette; Kathleen A Wallace; Najwa H Coates; Benjamin T Castellon; Eric A Grulke
Journal:  Cell Biol Toxicol       Date:  2022-07-25       Impact factor: 6.819

4.  Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity.

Authors:  Hsien W Chan; Tianbing Liu; Giuseppe Verdile; Glenda Bishop; Ryan J Haasl; Mark A Smith; George Perry; Ralph N Martins; Craig S Atwood
Journal:  Int J Clin Exp Med       Date:  2008-01-20

5.  Differential lowering by manganese treatment of activities of glycolytic and tricarboxylic acid (TCA) cycle enzymes investigated in neuroblastoma and astrocytoma cells is associated with manganese-induced cell death.

Authors:  Gaurangi V Malthankar; Brenda K White; Alok Bhushan; Christopher K Daniels; Kenneth J Rodnick; James C K Lai
Journal:  Neurochem Res       Date:  2004-04       Impact factor: 3.996

6.  Differential effects of metal ions on type A and type B monoamine oxidase activities in rat brain and liver mitochondria.

Authors:  T K Leung; L Lim; J C Lai
Journal:  Metab Brain Dis       Date:  1992-09       Impact factor: 3.584

Review 7.  Handling of Copper and Copper Oxide Nanoparticles by Astrocytes.

Authors:  Felix Bulcke; Ralf Dringen
Journal:  Neurochem Res       Date:  2015-08-13       Impact factor: 3.996
  7 in total

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