Observations on immune mechanisms in otitis media with effusion.

In this brief review of recent advances in immunological reactivity in otitis media, I have neither attempted to review the field from a historical perspective, nor attempted a critical analysis of the current status and future frontiers of this area. I have, rather, reviewed 5 areas that are being pursued in our laboratory and compare our investigations with those being performed throughout the country and abroad. It is my sincere hope that investigations into these areas will continue and will lead to potentially fruitful and meaningful data that will eventually unravel the mystery of persistent OME.