Epidermolytic palmo-plantar keratoderma.

An 11-year-old girl who at 9 1/2 months was diagnosed as having keratoderma of the palms and soles, present since birth, developed typical granuloma annulare at the age of 11 years. To the authors' knowledge, this is the first report of epidermolytic palmo-plantar keratoderma associated with granuloma annulare. There was no known family history of keratoderma. A review of the literature revealed three other patients without family history, although most of the patients have had multiple family members with the same problem. Many skin conditions can be associated with epidermolytic hyperkeratosis. The authors believe that epidermolytic palmo-planter keratoderma is a distinct form of palmo-plantar keratoderma rather than a type of ichthyosis.