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Literature DB >> 6240929

5-Hydroxytryptamine releasing activity in culture supernatants of guinea pig lymphocytes.

Abstract

5-Hydroxytryptamine (5-HT) is not only involved in anaphylactic reactions but also in delayed-type hypersensitivity (DTH) reactions. Supernatants of cultivated guinea pig spleen lymphocytes were investigated for possessing 5-HT releasing activity. Both fractionated supernatants of mixed lymphocytes unspecifically stimulated by Concanavalin A (Con A) and fractionated supernatants of non-stimulated mixed lymphocytes decrease the 5-HT content of rabbit thrombocytes. Fractions of a molecular weight smaller than 12,500 daltons are more effective than fractions of a higher molecular weight range. The 5-HT releasing activity of the supernatants is discussed in comparison to a cell migration stimulating activity.

Entities: Chemical Disease Species

Mesh：

Substances：
Concanavalin A
Serotonin

Year: 1984 PMID： 6240929 DOI： 10.1007/bf01972360

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

9 in total

1. [INVESTIGATIONS INTO THE LIBERATION OF SEROTONIN FROM THROMBOCYTES BY MEANS OF THROMBIN].

Authors: F MARKWARDT; W BARTHEL
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1964-10-13

2. Lymphokines and thrombosis. I. Thrombocyte aggregating activity released by human lymphocytes stimulated with concanavalin-A.

Authors: E Coeugniet; G Bendixen
Journal: Acta Allergol Date: 1976-04

3. Biological characterization of guinea pig lymphotoxin production.

Authors: J O Rundell; C H Evans
Journal: Immunopharmacology Date: 1979-12

Review 4. Inflammatory, non-antibody lymphocytic mediators (lymphokines).

Authors: K Bendtzen; G Bendixen
Journal: Allerg Immunol (Leipz) Date: 1980

5. Pharmacological studies on lymphocytes. 1. Effects of 5-hydroxytryptamine, bradykinin, and lymphokines on the migration of lymphocytes in vitro.

Authors: I Paegelow; P Lange
Journal: Agents Actions Suppl Date: 1982

6. Pharmacological studies on lymphocytes: 2. Effects of indole derivatives and their antagonists on the lymphocyte migration.

Authors: I Paegelow; P Lange
Journal: Agents Actions Date: 1984-10

2 in total

1. Studies on histamine releasing factor (HRF) of human, murine and guinea-pig origin.

Authors: R Alam; J Wyczółkowska; Z Sułowska
Journal: Agents Actions Date: 1986-04

2. Pharmacological studies on lymphocytes: 2. Effects of indole derivatives and their antagonists on the lymphocyte migration.