Literature DB >> 6240242

Multiple actions of steroids and their antagonists.

R E Whalen.   

Abstract

Our scientific language is often misleading. We speak, for example, of virilizing progestins when we should be speaking of "dihydrotestosterone-like" progestins because genital virilization is normally brought about by DHT. We speak of the anti-libidinal properties of antiandrogens as though we knew that their mechanism of action was through the blockage of androgen receptors; some of these agents are antiestrogenic and progestational as well. Until we know the mechanism of action of androgens, estrogens, antiandrogens, antiestrogens, aromatase inhibitors, and reductase inhibitors we should be cautious in our terminology. All hormones and their antagonists have multiple effects.

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Year:  1984        PMID: 6240242     DOI: 10.1007/bf01541432

Source DB:  PubMed          Journal:  Arch Sex Behav        ISSN: 0004-0002


  18 in total

1.  Antiandrogens in the treatment of sexual deviations of men.

Authors:  U Laschet; L Laschet
Journal:  J Steroid Biochem       Date:  1975-06       Impact factor: 4.292

2.  Biological studies on an anti-androgen (SH 714).

Authors:  R O Neri; M D Monahan; J G Meyer; B A Afonso; I A Tabachnick
Journal:  Eur J Pharmacol       Date:  1967-09       Impact factor: 4.432

3.  Induction of receptivity in female rats and cats with estrogen and testosterone.

Authors:  R E Whalen; D F Hardy
Journal:  Physiol Behav       Date:  1970-04

4.  Prenatal exposure to synthetic progestins increases potential for aggression in humans.

Authors:  J M Reinisch
Journal:  Science       Date:  1981-03-13       Impact factor: 47.728

Review 5.  The hormonal control of sexual development.

Authors:  J D Wilson; F W George; J E Griffin
Journal:  Science       Date:  1981-03-20       Impact factor: 47.728

6.  Role of aromatization in sexual differentiation: effects of prenatal ATD treatment and neonatal castration.

Authors:  R E Whalen; K L Olsen
Journal:  Horm Behav       Date:  1981-06       Impact factor: 3.587

7.  Effect of anti-androgen and 5 alpha-reductase inhibitor on hormone-induced sexual behavior during pregnancy in the rat.

Authors:  M S Erskine; J I Marcus; M J Baum
Journal:  Biol Reprod       Date:  1980-11       Impact factor: 4.285

8.  Facilitation of male sexual behavior in adult male rats by the aromatization inhibitor, 1,4,6-androstatriene-3,17-dione (ATD).

Authors:  I T Landau
Journal:  Physiol Behav       Date:  1980-08

9.  Effects of prenatal sex hormones on gender-related behavior.

Authors:  A A Ehrhardt; H F Meyer-Bahlburg
Journal:  Science       Date:  1981-03-20       Impact factor: 47.728

10.  Virilization of female rats by prenatally administered progestin.

Authors:  R E Whalen; C K Peck; J LoPiccolo
Journal:  Endocrinology       Date:  1966-05       Impact factor: 4.736

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  1 in total

1.  Testosterone in utero and at birth dictates how stressful experience will affect learning in adulthood.

Authors:  Tracey J Shors; George Miesegaes
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-01       Impact factor: 11.205

  1 in total

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