Literature DB >> 6239902

In vivo and in vitro characterization of specific hyporeactivity to skin xenografts in mixed xenogeneically reconstituted mice (B10 + F344 rat----B10).

S T Ildstad, S M Wren, S O Sharrow, D Stephany, D H Sachs.   

Abstract

Mixed xenogeneically reconstituted mice (F344 rat + C57BL/10Sn----C57BL/10Sn), which specifically retain F344 tail skin xenografts, were studied for the specificity of such hyporeactivity and for in vitro reactivity and immunocompetence. Survival of mixed reconstituted animals was excellent, without evidence for graft vs. host disease. Donor-type tail skin grafts were specifically prolonged (mean survival time = 80 d) in comparison with normal controls and syngeneically reconstituted animals. In vitro, such animals manifested specific hyporeactivity by mixed lymphocyte reaction and cell-mediated lympholysis to F344 rat and B10 cells, with normal response to third-party rat (Wistar-Furth) and mouse (B10.BR). Examination of lymphoid tissues with a fluorescence-activated cell sorter revealed low levels, if any, of donor-type cells detectable. This system offers a model for investigation of xenogeneic transplantation tolerance.

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Year:  1984        PMID： 6239902      PMCID： PMC2187530          DOI： 10.1084/jem.160.6.1820

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  20 in total

Review 1.  Cellular factors. Immunologic tolerance: irradiation and bone marrow transplantation in induction of canine allogeneic unresponsiveness.

Authors:  F T Rapaport; R J Bachvaroff; K Watanabe; H Hirasawa; F D Cannon; N Mollen; D A Blumenstock; J H Ayvazian; J W Ferrebee
Journal:  Transplant Proc       Date:  1977-03       Impact factor: 1.066

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Authors:  E C JONES; P L KROHN
Journal:  J Endocrinol       Date:  1960-04       Impact factor: 4.286

3.  Successful cardiac allografts in syngeneic radiation chimeras.

Authors:  J Dittmer; M Bennett
Journal:  Mol Cell Biochem       Date:  1978-11-01       Impact factor: 3.396

4.  Induction of lasting hemopoietic chimerism in a xenogeneic (rat to mouse) model.

Authors:  W Müller-Ruchholtz; H K Müller-Hermelink; H U Wottge
Journal:  Transplant Proc       Date:  1979-03       Impact factor: 1.066

5.  Neonatal tolerance induction across regions of H-2 complex.

Authors:  J W Streilein; J Klein
Journal:  J Immunol       Date:  1977-12       Impact factor: 5.422

6.  Cellular and genetic control of antibody responses in vitro. I. Cellular requirements for the generation of genetically controlled primary IgM responses to soluble antigens.

Authors:  R J Hodes; A Singer
Journal:  Eur J Immunol       Date:  1977-12       Impact factor: 5.532

7.  Rejection of skin allografts by radiation chimaeras: selective gene action in the specification of cell surface structure.

Authors:  E A Boyse; E M Lance; E A Carswell; S Cooper; L J Old
Journal:  Nature       Date:  1970-08-29       Impact factor: 49.962

8.  Inhibition of stimulation in murine mixed lymphocyte cultures with an alloantiserum directed against a shared Ia determinant.

Authors:  R H Schwartz; C G Fathman; D H Sachs
Journal:  J Immunol       Date:  1976-04       Impact factor: 5.422

9.  Cellular and genetic control of antibody responses. V. Helper T-cell recognition of H-2 determinants on accessory cells but not B cells.

Authors:  A Singer; K S Hathcock; R J Hodes
Journal:  J Exp Med       Date:  1979-05-01       Impact factor: 14.307

10.  Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts.

Authors:  S Slavin; S Strober; Z Fuks; H S Kaplan
Journal:  J Exp Med       Date:  1977-07-01       Impact factor: 14.307
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  10 in total

1.  Rat stem cells developing in irradiated SCID mice fail to become tolerized and cause lethal graft-versus-host disease.

Authors:  C D Surh; H Kosaka; J Sprent
Journal:  Am J Pathol       Date:  1997-08       Impact factor: 4.307

2.  Induction of Pancreatic Islet Graft Acceptance: The Role of Antigen Presenting Cells.

Authors:  Camillo Ricordi; Suzanne T Ildstad; Thomas E Starzl
Journal:  Transplant Sci       Date:  1992-04

3.  Induction of stable chimerism and elimination of graft-versus-host disease by depletion of T lymphocytes from bone marrow using immunomagnetic beads.

Authors:  A L Hoffman; L Makowka; D V Cramer; X Cai; B Banner; A Pascualone; S Hoffmann; T E Starzl
Journal:  Surgery       Date:  1989-08       Impact factor: 3.982

4.  Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat.

Authors:  J M Langrehr; N Murase; P M Markus; X Cai; P Neuhaus; W Schraut; R L Simmons; R A Hoffman
Journal:  J Clin Invest       Date:  1992-08       Impact factor: 14.808

Review 5.  Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism.

Authors:  Carrie Gibbons; Megan Sykes
Journal:  Immunol Rev       Date:  2008-06       Impact factor: 12.988

6.  Long-term survival of donor-specific pancreatic islet xenografts in fully xenogeneic chimeras (WF rat----B10 mouse).

Authors:  Y J Zeng; C Ricordi; A Tzakis; H L Rilo; P B Carroll; T E Starzl; S T Ildstad
Journal:  Transplantation       Date:  1992-02       Impact factor: 4.939

7.  Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats.

Authors:  N Murase; T E Starzl; M Tanabe; S Fujisaki; H Miyazawa; Q Ye; C P Delaney; J J Fung; A J Demetris
Journal:  Transplantation       Date:  1995-07-27       Impact factor: 4.939

Review 8.  Immunologic tolerance to organ transplants.

Authors:  D H Sachs
Journal:  J Gastrointest Surg       Date:  1999 Mar-Apr       Impact factor: 3.267

9.  Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance.

Authors:  S T Ildstad; S M Wren; J A Bluestone; S A Barbieri; D H Sachs
Journal:  J Exp Med       Date:  1985-07-01       Impact factor: 14.307

10.  Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen.

Authors:  Y Sharabi; I Aksentijevich; T M Sundt; D H Sachs; M Sykes
Journal:  J Exp Med       Date:  1990-07-01       Impact factor: 14.307
  10 in total

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