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Literature DB >> 6239785

Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).

J A Engel, S Hjorth, K Svensson, A Carlsson, S Liljequist.

Abstract

The putative 5-HT agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT) produced in rats an increase in the number of shocks accepted in a modified Vogel's conflict test design. Subchronic pretreatment with p-chlorophenylalanine (PCPA) similarly caused release of the punished behavior. This anticonflict effect of PCPA was antagonized by both 5-hydrotryptophan and 8-OH-DPAT. Thus in naive animals 8-OH-DPAT exerting anticonflict effects acted like a 5-HT antagonist, whereas in subchronically PCPA-pretreated animals with presumably supersensitive 5-HT receptors, 8-OH-DPAT decreasing the number of accepted shocks acted like a 5-HT agonist.

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Year: 1984 PMID： 6239785 DOI： 10.1016/0014-2999(84)90634-4

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

46 in total

1. Species differences in the mechanism through which the serotonergic agonists indorenate and ipsapirone produce their anxiolytic action.

Authors: A Fernández-Guasti; E Hong; C López-Rubalcava
Journal: Psychopharmacology (Berl) Date: 1992 Impact factor: 4.530

10. Effects of blockade of 5-HT2 receptors and activation of 5-HT1A receptors on the exploratory activity of rats in the elevated plus-maze.

Authors: V Motta; S Maisonnette; S Morato; P Castrechini; M L Brandão
Journal: Psychopharmacology (Berl) Date: 1992 Impact factor: 4.530

Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).

1. Species differences in the mechanism through which the serotonergic agonists indorenate and ipsapirone produce their anxiolytic action.

2. Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection.

Review 3. 5-HT1A partial agonists. What is their future?

4. 8-OH-DPAT-induced place preference and place aversion: effects of PCPA and dopamine antagonists.

5. Evidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone.

6. Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test.

7. Blockade of 8-OH-DPAT-induced feeding by dopamine antagonists.

8. Evidence for selective inhibition of limbic forebrain dopamine synthesis by 8-OH-DPAT in the rat.

9. Serotonergic influences on male sexual behavior of rhesus monkeys: effects of serotonin agonists.

10. Effects of blockade of 5-HT2 receptors and activation of 5-HT1A receptors on the exploratory activity of rats in the elevated plus-maze.