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Literature DB >> 6239721

Reactivity of Leu 1 and T101 monoclonal antibodies with B cell lymphomas (correlations with other immunological markers).

T Al Saati, G Laurent, P Caveriviere, F Rigal, G Delsol.

Abstract

The reactivity of Leu 1/T101 monoclonal antibodies (MoAb) was studied in a series of 69 lymphomas with B cell differentiation and was correlated with other cell markers. A three step immunoperoxidase technique on frozen sections was used to test a panel of 20 MoAb: anti-human Ig (heavy and light chains), To 15 (Pan B cells), Leu 1, T101, Leu 4, Leu 3a, Leu 5, OKT 8, OKT 6, Leu 7, anti-CALLA (IOT 5), Leu 10, anti-HLA-DR, OKM 1 and anti-dendritic reticulum cells (R 4/23). T101/Leu 1 antigen was detected in 24 cases: CLL (11 of 11), diffuse centrocytic lymphomas (four of 11), follicular lymphomas (none of 12), follicular and diffuse lymphomas (seven of 10) and one unclassified low grade lymphoma. This antigen was observed in only one high grade malignant lymphoma. In follicular lymphomas, two results deserve attention: (1) T101+ lymphomas showed most frequently IgM+, IgD+ surface Ig. Inversely, T101 unreactive lymphomas displayed IgM+, IgD+ phenotype. (2) Tp67 antigen (T101, Leu 1) and CALLA (GP 100) were found to be mutually exclusive in these lymphomas. These results suggest that follicular lymphomas could be derived from two distinct germinal center cell populations: IgM+ Ig'D-, Calla+, Leu 1-/T101- and IgM+, IgD+, CALLA-, Leu+/T101+.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1984 PMID： 6239721 PMCID： PMC1577094

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

20 in total

1. A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells.

Authors: E L Reinherz; P C Kung; G Goldstein; S F Schlossman
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2. Studies of a human T lymphocyte antigen recognized by a monoclonal antibody.

Authors: E G Engleman; R Warnke; R I Fox; J Dilley; C J Benike; R Levy
Journal: Proc Natl Acad Sci U S A Date: 1981-03 Impact factor: 11.205

3. A novel human T cell antigen preferentially expressed on mature T cells and shared by both well and poorly differentiated B cell leukemias and lymphomas.

Authors: M Kamoun; M E Kadin; P J Martin; J Nettleton; J A Hansen
Journal: J Immunol Date: 1981-09 Impact factor: 5.422

4. A new human T-cell differentiation antigen: unexpected expression on chronic lymphocytic leukemia cells.

Authors: P J Martin; J A Hansen; R C Nowinski; M A Brown
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

5. Immunologic classification of lymphocytic leukemias based on monoclonal antibody-defined cell surface antigens.

Authors: R W Schroff; K A Foon; R J Billing; J L Fahey
Journal: Blood Date: 1982-02 Impact factor: 22.113

6. Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin.

Authors: I Royston; J A Majda; S M Baird; B L Meserve; J C Griffiths
Journal: J Immunol Date: 1980-08 Impact factor: 5.422

7. Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia.

Authors: F Caligaris-Cappio; M Gobbi; M Bofill; G Janossy
Journal: J Exp Med Date: 1982-02-01 Impact factor: 14.307

8. An antigen shared by a human T cell subset and B cell chronic lymphocytic leukemic cells. Distribution on normal and malignant lymphoid cells.

Authors: L Boumsell; H Coppin; D Pham; B Raynal; J Lemerle; J Dausset; A Bernard
Journal: J Exp Med Date: 1980-07-01 Impact factor: 14.307

9. Malignant lymphoma with dual B and T cell markers. Analysis of the neoplastic cells with monoclonal antibodies directed against T cell subsets.

Authors: A C Aisenberg; K J Bloch; B M Wilkes
Journal: J Exp Med Date: 1981-11-01 Impact factor: 14.307

10. T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.

Authors: J A Ledbetter; R V Rouse; H S Micklem; L A Herzenberg
Journal: J Exp Med Date: 1980-08-01 Impact factor: 14.307

5 in total

1. Coexpression of epithelial membrane antigen (EMA), Ki-1, and interleukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis.

Authors: G Delsol; T Al Saati; K C Gatter; J Gerdes; R Schwarting; P Caveriviere; F Rigal-Huguet; A Robert; H Stein; D Y Mason
Journal: Am J Pathol Date: 1988-01 Impact factor: 4.307