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Literature DB >> 6239686

Immunomodulation and therapeutic characterization of thymosin fraction five.

J E Talmadge, K A Uithoven, B F Lenz, M Chirigos.

Abstract

In this report we describe the characterization of the immunomodulatory efficiency and therapeutic properties of thymosin fraction five (F5). We consistently observed the immunostimulation of T-cell activity in assays of allogeneic mixed lymphocyte response (MLR) and the development of cytotoxic effector cells in an allogeneic mixed lymphocyte tumor response-cell-mediated cytotoxicity assay (MLTR-CMC). No induction of suppressor cell activity was observed. Thymosin F5 also acted successfully as an adjuvant when admixed with irradiated tumor cells. We were unable to demonstrate either NK cell or macrophage activation by thymosin F5. Therapeutic protocols using thymosin F5 and directed against pre-existing experimental and spontaneous metastases, had a significant immunotherapeutic potential.

Entities: Disease

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Year: 1984 PMID： 6239686 DOI： 10.1007/bf00205510

Source DB: PubMed Journal: Cancer Immunol Immunother ISSN： 0340-7004 Impact factor: 6.968

33 in total

1. A transplantable mast-cell neoplasm in the mouse.

Authors: T B DUNN; M POTTER
Journal: J Natl Cancer Inst Date: 1957-04 Impact factor: 13.506

2. T-lymphocyte maturation: cell surface markers and immune function induced by T-lymphocyte cell-free products and thymosin polypeptides.

Authors: A Ahmed; D M Wong; G B Thurman; T L Low; A L Goldstein; S J Sharkis; I Goldschneider
Journal: Ann N Y Acad Sci Date: 1979 Impact factor: 5.691

3. Thymosin modulation of regulatory T cell function.

Authors: M G Mutchnick; J A Prieto; J A Schaffner; F E Weller
Journal: Clin Immunol Immunopathol Date: 1982-06

4. Enhancement of murine thymocyte cytotoxic T cell responses by thymosin.

Authors: M M Zatz; A L Goldstein
Journal: Immunopharmacology Date: 1983-06

5. The selection and characterization of an invasive variant of the B16 melanoma.

Authors: I R Hart
Journal: Am J Pathol Date: 1979-12 Impact factor: 4.307

6. Induction of terminal deoxynucleotidyl transferase and Lyt antigens with thymosin: identification of multiple subsets of prothymocytes in mouse bone marrow and spleen.

Authors: I Goldschneider; A Ahmed; F J Bollum; A L Goldstein
Journal: Proc Natl Acad Sci U S A Date: 1981-04 Impact factor: 11.205

7. The relative proliferation index as a more sensitive parameter for evaluating lymphoproliferative responses of cancer patients to mitogens and alloantigens.

Authors: J H Dean; R Connor; R B Herberman; J Silva; J L McCoy; R K Oldham
Journal: Int J Cancer Date: 1977-09-15 Impact factor: 7.396

8. Macrophage content of metastatic and nonmetastatic rodent neoplasms.

Authors: J E Talmadge; M Key; I J Fidler
Journal: J Immunol Date: 1981-06 Impact factor: 5.422

9. Resistance to L1210 mouse leukemia cells in moderately protein-malnourished BALB/c mice treated in vivo with thymosin fraction V.

Authors: T M Petro; R R Watson
Journal: Cancer Res Date: 1982-06 Impact factor: 12.701

10. Modification by biological products of the generation of suppressor cells in culture.

Authors: K H Leung; M J Ehrke; E Mihich
Journal: Immunopharmacology Date: 1983-02

4 in total

Review 1. Thymic hormones--a clinical update.

Authors: M B Sztein; A L Goldstein
Journal: Springer Semin Immunopathol Date: 1986