Literature DB >> 6239298

Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain.

T Lee, S W Tang.   

Abstract

Chronic administration of loxapine or clozapine in rats for 4 weeks or 10 weeks did not produce enhancement of striatal dopamine receptor density. However, there was a marked reduction (50-60%) of cortical serotonin receptor density associated with clozapine or loxapine administration. Acute doses of clozapine or loxapine produced the same potent effect. The possibility that these two antipsychotic drugs act via the serotonin system in the brain is proposed.

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Year:  1984        PMID： 6239298     DOI： 10.1016/0165-1781(84)90044-1

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  12 in total

Review 1.  Clinical profile of clozapine: adverse reactions and agranulocytosis.

Authors:  J A Lieberman; A Z Safferman
Journal:  Psychiatr Q       Date:  1992

2.  Atypical neuroleptics suppress dopaminergic behavioral supersensitivity.

Authors:  C Schremmer; R Morgenstern; H Fink; T Ott
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

3.  Long-term treatment with haloperidol or clozapine does not affect dopamine D4 receptors in rat frontal cortex.

Authors:  I Kusumi; T Ishikane; S Matsubara; T Koyama
Journal:  J Neural Transm Gen Sect       Date:  1995

Review 4.  Mechanisms of action of atypical antipsychotic drugs: a critical analysis.

Authors:  B J Kinon; J A Lieberman
Journal:  Psychopharmacology (Berl)       Date:  1996-03       Impact factor: 4.530

5.  Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients.

Authors:  R C Arora; H Y Meltzer
Journal:  J Neural Transm Gen Sect       Date:  1991

6.  Seroquel: biochemical profile of a potential atypical antipsychotic.

Authors:  C F Saller; A I Salama
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

7.  Effects of clozapine and 2,5-dimethoxy-4-methylamphetamine [DOM] on 5-HT2A receptor expression in discrete brain areas.

Authors:  M M Doat-Meyerhoefer; R Hard; J C Winter; R A Rabin
Journal:  Pharmacol Biochem Behav       Date:  2005-08       Impact factor: 3.533

Review 8.  Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia.

Authors:  A Fitton; R C Heel
Journal:  Drugs       Date:  1990-11       Impact factor: 9.546

9.  A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes.

Authors:  A N Singh; C Barlas; S Singh; P Franks; R K Mishra
Journal:  J Psychiatry Neurosci       Date:  1996-01       Impact factor: 6.186

Review 10.  The dopamine hypothesis of schizophrenia: limbic interactions with serotonin and norepinephrine.

Authors:  J N Joyce
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530
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