Literature DB >> 6238907

Inhibition of in vitro immunosuppressive effects of glucocorticosteroids by a competitive antagonist RU-486.

D Emilie, P Galanaud, E E Baulieu, J Dormont.   

Abstract

The 19-nor-steroid RU-486 is an antagonist of glucocorticosteroids acting competitively at the receptor level. Pharmacological and endocrinological studies have already shown that RU-486 is able to reverse glucocorticosteroid effects. The present study shows that RU-486 can counteract the inhibitory effect of glucocorticosteroids in two highly corticoid-sensitive in vitro immune responses: murine in vitro antibody response and human autologous mixed lymphocyte reaction.

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Year:  1984        PMID： 6238907     DOI： 10.1016/0165-2478(84)90075-0

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  2 in total

1.  Sparfloxacin, ethambutol, and cortisol receptor inhibitor RU-40 555 treatment for disseminated Mycobacterium avium complex infection of normal C57BL/6 mice.

Authors:  C Perronne; Y Cohen; C Truffot-Pernot; J Grosset; J L Vildé; J J Pocidalo
Journal:  Antimicrob Agents Chemother       Date:  1992-11       Impact factor: 5.191

2.  Psychological stress impairs the local CD8+ T cell response to mucosal HSV-1 infection and allows for increased pathogenicity via a glucocorticoid receptor-mediated mechanism.

Authors:  Kathleen A Ashcraft; John Hunzeker; Robert H Bonneau
Journal:  Psychoneuroendocrinology       Date:  2008-07-25       Impact factor: 4.905
  2 in total

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