Literature DB >> 6238844

Increased content of natural ATPase inhibitor in tumor mitochondria.

K Luciaková, S Kuzela.   

Abstract

The ATPase activity of Zajdela hepatoma and Yoshida sarcoma submitochondrial particles was several times lower than the enzyme activity in rat heart and rat liver submitochondrial particles. The content of F1-ATPase in the tumor mitochondria was found not to be very different from that in mitochondria of rat liver. Immunochemical determination of the amount of the natural ATPase inhibitor revealed that the tumor mitochondria contain 2-3-times more ATPase inhibitor than control mitochondria. It is concluded that the low ATPase activity of the tumor mitochondria results from the inhibition of the enzyme activity by the natural ATPase inhibitor.

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Year:  1984        PMID： 6238844     DOI： 10.1016/0014-5793(84)80986-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

Review 1.  Regulation of the mitochondrial ATPase in situ in cardiac muscle: role of the inhibitor subunit.

Authors:  W Rouslin
Journal:  J Bioenerg Biomembr       Date:  1991-12       Impact factor: 2.945

2.  The inhibitor protein (IF1) of the F1F0-ATPase modulates human osteosarcoma cell bioenergetics.

Authors:  Simona Barbato; Gianluca Sgarbi; Giulia Gorini; Alessandra Baracca; Giancarlo Solaini
Journal:  J Biol Chem       Date:  2015-01-20       Impact factor: 5.157

3.  The Ca2+ threshold for the mitochondrial permeability transition and the content of proteins related to Bcl-2 in rat liver and Zajdela hepatoma mitochondria.

Authors:  Y V Evtodienko; V V Teplova; T S Azarashvily; A Kudin; O Prusakova; I Virtanen; N E Saris
Journal:  Mol Cell Biochem       Date:  1999-04       Impact factor: 3.396

4.  Increased amount of a mitochondria-associated 21 x 10(3) dalton protein in human gastrointestinal tumors.

Authors:  C Welter; G Reichert; K D Zang
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

Review 5.  Oxidative phosphorylation enzymes in normal and neoplastic cell growth.

Authors:  F Capuano; F Guerrieri; S Papa
Journal:  J Bioenerg Biomembr       Date:  1997-08       Impact factor: 2.945

6.  Overexpression of the inhibitor protein IF(1) in AS-30D hepatoma produces a higher association with mitochondrial F(1)F(0) ATP synthase compared to normal rat liver: functional and cross-linking studies.

Authors:  Concepción Bravo; Fernando Minauro-Sanmiguel; Edgar Morales-Ríos; José S Rodríguez-Zavala; José J García
Journal:  J Bioenerg Biomembr       Date:  2004-06       Impact factor: 2.945

7.  IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation.

Authors:  L Shen; L Zhi; W Hu; M X Wu
Journal:  Cell Death Differ       Date:  2008-12-19       Impact factor: 15.828

8.  Glucose-modulated mitochondria adaptation in tumor cells: a focus on ATP synthase and inhibitor Factor 1.

Authors:  Rossana Domenis; Elena Bisetto; Davide Rossi; Marina Comelli; Irene Mavelli
Journal:  Int J Mol Sci       Date:  2012-02-10       Impact factor: 6.208

9.  Molecular Regulation of the Mitochondrial F(1)F(o)-ATPsynthase: Physiological and Pathological Significance of the Inhibitory Factor 1 (IF(1)).

Authors:  Danilo Faccenda; Michelangelo Campanella
Journal:  Int J Cell Biol       Date:  2012-08-26

10.  The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase.

Authors:  Fabrice Ivanes; Danilo Faccenda; Jemma Gatliff; Ahmed A Ahmed; Stefania Cocco; Carol Ho Ka Cheng; Emma Allan; Claire Russell; Michael R Duchen; Michelangelo Campanella
Journal:  Br J Pharmacol       Date:  2014-07-01       Impact factor: 8.739
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