Literature DB >> 6238565

Advanced grandmaternal age on the mother's side--a risk of giving rise to trisomy 21.

L Aagesen, J Grinsted, M Mikkelsen.   

Abstract

The age distribution of maternal grandmothers of children with Down syndrome was compared with paternal grandparents of the same group and with grandparents of healthy children (controls). The significant advanced maternal grandmaternal age was found in cases of Down syndrome caused by first meiotic error in the maternal oogenesis. The advanced maternal grandmaternal age was found independent of maternal age. No differences were found between the ages of grandfathers of Down syndrome and of controls.

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Year:  1984        PMID： 6238565     DOI： 10.1111/j.1469-1809.1984.tb00843.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  8 in total

1.  Selective advantage of fra (X) heterozygotes compared with mothers of Down syndrome probands?

Authors:  P H Jongbloet
Journal:  Hum Genet       Date:  1992-03       Impact factor: 4.132

Review 2.  The contribution of mitochondrial function to reproductive aging.

Authors:  Yaakov Bentov; Tetyana Yavorska; Navid Esfandiari; Andrea Jurisicova; Robert F Casper
Journal:  J Assist Reprod Genet       Date:  2011-05-27       Impact factor: 3.412

3.  Does the karyotype of a spontaneous abortion predict the karyotype of a subsequent abortion? Evidence from 273 women with two karyotyped spontaneous abortions.

Authors:  D Warburton; J Kline; Z Stein; M Hutzler; A Chin; T Hassold
Journal:  Am J Hum Genet       Date:  1987-09       Impact factor: 11.025

4.  Maternal age and risk for trisomy 21 assessed by the origin of chromosome nondisjunction: a report from the Atlanta and National Down Syndrome Projects.

Authors:  Emily Graves Allen; Sallie B Freeman; Charlotte Druschel; Charlotte A Hobbs; Leslie A O'Leary; Paul A Romitti; Marjorie H Royle; Claudine P Torfs; Stephanie L Sherman
Journal:  Hum Genet       Date:  2008-12-03       Impact factor: 4.132

5.  Germ-line transmission of trisomy 21: Data from 80 families suggest an implication of grandmaternal age and a high frequency of female-specific trisomy rescue.

Authors:  Natalia V Kovaleva
Journal:  Mol Cytogenet       Date:  2010-03-18       Impact factor: 2.009

Review 6.  The ageing ovary and uterus: new biological insights.

Authors:  S M Nelson; E E Telfer; R A Anderson
Journal:  Hum Reprod Update       Date:  2012-10-26       Impact factor: 15.610

7.  Influence of advanced age of maternal grandmothers on Down syndrome.

Authors:  Suttur S Malini; Nallur B Ramachandra
Journal:  BMC Med Genet       Date:  2006-01-14       Impact factor: 2.103

Review 8.  Oocyte ageing and epigenetics.

Authors:  Zhao-Jia Ge; Heide Schatten; Cui-Lian Zhang; Qing-Yuan Sun
Journal:  Reproduction       Date:  2014-11-12       Impact factor: 3.906
  8 in total

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