Literature DB >> 6237927

N,N-disubstituted 2-aminotetralins are potent D-2 dopamine receptor agonists.

M Beaulieu, Y Itoh, P Tepper, A S Horn, J W Kebabian.   

Abstract

Mono- and di-N-substituted 2-amino-5-hydroxytetralins stimulate the D-2 dopamine receptor, 2-(N-n-propyl-N-phenylethylamino)-5-hydroxytetralin being the most potent D-2 agonist encountered to date. In contrast, 2-amino-5-hydroxytetralins only marginally stimulate the D-1 receptor; however, 2-(di-N-n-propylamino)-5, 6-dihydroxytetralin is equipotent with dopamine as a D-1 agonist. The results are discussed within the context of the two dopamine receptor hypothesis.

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Year:  1984        PMID： 6237927     DOI： 10.1016/0014-2999(84)90644-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  In vivo receptor binding, neurochemical and functional studies with the dopamine D-1 receptor antagonist SCH23390.

Authors:  S Hjorth; A Carlsson
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

2.  Radioreceptor binding reveals the potencies of N,N-disubstituted 2-aminotetralins as D2 dopamine agonists.

Authors:  P M Beart; C J Cook; M Cincotta; D J de Vries; P Tepper; D Dijkstra; A S Horn
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-11       Impact factor: 3.000

3.  Development of a radioreceptor assay for the D2-selective dopamine agonist N-0437.

Authors:  K Ensing; D A Bloemhof; W G in 't Hout; J van der Lende; R A de Zeeuw
Journal:  Pharm Res       Date:  1988-05       Impact factor: 4.200

4.  Pharmacological profile of non-hydroxylated and ether derivatives of the potent D2-selective agonist N-0437.

Authors:  J M Jansen; I den Daas; H Rollema; P J Swart; P G Tepper; J B de Vries; A S Horn
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-02       Impact factor: 3.000

Review 5.  Potential of transdermal drug delivery in Parkinson's disease.

Authors:  Ronald F Pfeiffer
Journal:  Drugs Aging       Date:  2002       Impact factor: 3.923

6.  Synthesis and radioreceptor binding activity of N-0437, a new, extremely potent and selective D2 dopamine receptor agonist.

Authors:  A S Horn; P Tepper; J Van der Weide; M Watanabe; D Grigoriadis; P Seeman
Journal:  Pharm Weekbl Sci       Date:  1985-10-25

7.  Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin.

Authors:  T B Mulder; J B de Vries; D Dijkstra; J W Wiechers; C J Grol; A S Horn
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-11       Impact factor: 3.000

8.  The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour.

Authors:  S J Cooper; J Francis; I N Rusk
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530
  8 in total

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