Literature DB >> 623690

Direct evidence for circulating DNA/anti-DNA complexes in systemic lupus erythematosus.

J S Davis, S M Godfrey, J B Winfield.   

Abstract

Fifteen serum cryoprecipitates from 28 patients with systemic lupus erythematosus (SLE) contained DNA demonstrable by counterimmunoelectrophoresis after exhaustive digestion of cryoimmunoglobulin with pronase. The majority of these cryoprecipitates also exhibited increased DNA binding activity in a modified Farr assay. Both DNA and anti-DNA antibody were enriched in the cryoprecipitates relative to the supernatant serum level. These data provide direct evidence for the presence of DNA/anti-DNA complexes in the circulation of patients with SLE.

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Year:  1978        PMID： 623690     DOI： 10.1002/art.1780210104

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  22 in total

Review 1.  Antiendothelial cell antibodies (AECA) in systemic lupus erythematosus (SLE).

Authors:  D D'Cruz; M Khamashta; G Hughes
Journal:  Clin Rev Allergy Immunol       Date:  1997       Impact factor: 8.667

2.  Low avidity antibodies to double stranded DNA in systemic lupus erythematosus: a longitudinal study of their clinical significance.

Authors:  J C Nossent; V Huysen; R J Smeenk; A J Swaak
Journal:  Ann Rheum Dis       Date:  1989-08       Impact factor: 19.103

3.  Platelet-aggregating immune complexes and intraplatelet serotonin in idiopathic glomerulonephritis and systemic lupus.

Authors:  N Kasai; A Parbtani; J S Cameron; V Yewdall; P Shepherd; P Verroust
Journal:  Clin Exp Immunol       Date:  1981-01       Impact factor: 4.330

4.  Glomerular lesions induced in the rabbit by physicochemically altered homologous IgG.

Authors:  F Cavalot; M Miyata; A Vladutiu; V Terranova; S Dubiski; R Burlingame; E Tan; J Brentjens; F Milgrom; G Andres
Journal:  Am J Pathol       Date:  1992-03       Impact factor: 4.307

5.  Complement activating cryoglobulins in the nephritis of systemic lupus erythematosus.

Authors:  D Adu; D G Williams
Journal:  Clin Exp Immunol       Date:  1984-03       Impact factor: 4.330

6.  The association of cryoglobulinaemia with nodules, vasculitis and fibrosing alveolitis in rheumatoid arthritis and their relationship to serum C1q binding activity and rheumatoid factor.

Authors:  C C Erhardt; P Mumford; R N Maini
Journal:  Clin Exp Immunol       Date:  1979-12       Impact factor: 4.330

7.  Characterization of DNA in polyethylene glycol precipitated immune complexes from sera of patients with systemic lupus erythematosus.

Authors:  K Ikebe; R C Gupta; E M Tan
Journal:  Clin Exp Immunol       Date:  1983-10       Impact factor: 4.330

8.  Differences in immunochemical characteristics of cryoglobulins in rheumatoid arthritis and systemic lupus erythematosus and their complement binding properties.

Authors:  C C Erhardt; P Mumford; R N Maini
Journal:  Ann Rheum Dis       Date:  1984-06       Impact factor: 19.103

9.  DNA-anti-DNA circulating complexes in the nephritis of systemic lupus erythematosus.

Authors:  D Adu; J Dobson; D G Williams
Journal:  Clin Exp Immunol       Date:  1981-03       Impact factor: 4.330

Review 10.  Clinical significance of antibodies to double stranded DNA (dsDNA) for systemic lupus erythematosus (SLE).

Authors:  T Swaak; R Smeenk
Journal:  Clin Rheumatol       Date:  1987-06       Impact factor: 2.980
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