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Literature DB >> 6235287

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

J Kaye, S Gillis, S B Mizel, E M Shevach, T R Malek, C A Dinarello, L B Lachman, C A Janeway.

Abstract

By using as an experimental system the induction of growth of a cloned, antigen:Ia-reactive helper T cell line by an antigen receptor-specific monoclonal antibody, we demonstrated that growth requires two essential co-factors, exogenously produced IL 1 and endogenously produced IL 2. The primary role of the IL 1 is in the expression of receptors on the T cell surface for IL 2, rather than for promoting the synthesis of IL 2. The use of a clone-specific activating monoclonal antibody at nanogram amounts to activate a cloned helper T cell should allow a detailed characterization of T cell activation via antigen receptor cross-linking.

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Year: 1984 PMID： 6235287

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

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Cited

137 in total

1. Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.

Authors: T M Mahon; J S Matthews; L A O'Neill
Journal: Biochem J Date: 1997-07-01 Impact factor: 3.857

2. Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.

Authors: Y Liu; C A Janeway
Journal: Proc Natl Acad Sci U S A Date: 1992-05-01 Impact factor: 11.205

9. "Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.

Authors: T F Gajewski; D W Lancki; R Stack; F W Fitch
Journal: J Exp Med Date: 1994-02-01 Impact factor: 14.307

10. Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens.

Authors: A Ayala; M M Perrin; I H Chaudry
Journal: Immunology Date: 1990-05 Impact factor: 7.397

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1. Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.

2. Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.

3. Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation.

4. Involvement of gamma interferon in antibody enhancement by adjuvants.

5. Role of interleukin 1 in the activation of T lymphocytes.

6. Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.

7. Activation and proliferation of normal resting human T lymphocytes in serum-free culture: role of IL-4 and IL-6.

8. Interleukin 2 receptor bearing T lymphocytes in patients with chronic liver disease.

9. "Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.

10. Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens.