Literature DB >> 6235180

Lectins and substitution for helper function in anti-hapten responses in Xenopus laevis.

R H Clothier, H S James, L N Ruben, M Balls.   

Abstract

Substitution by lectins for the carrier-priming requirement in thymus-dependent, antigen-binding responses in Xenopus laevis has been examined. Concanavalin A (Con A) was found to substitute for carrier priming in control, early-thymectomized and adult-thymectomized animals, but not in animals given a single, high dose of N-methyl-N-nitrosourea, which has a permanent effect on certain thymus-dependent functions in this species. Lipopolysaccharide and other lectins, such as peanut agglutinin and wheat germ agglutinin, were unable to substitute for carrier priming. These effects of Con A are discussed in terms of substitution via amplifier T cells or a helper T cell subset.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6235180      PMCID： PMC1454662     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  26 in total

1.  Suppression and enhancement of the T cell-dependent production of antibody to SRBC in vitro by bacterial lipopolysaccharide.

Authors:  M K Hoffmann; O Weiss; S Koenig; J A Hirst; H F Oettgen
Journal:  J Immunol       Date:  1975-02       Impact factor: 5.422

2.  The effect of thymectomy at different stages of larval development on the immune response of the clawed toad to sheep erythrocytes.

Authors:  J D Horton; J J Rimmer; T L Horton
Journal:  J Exp Zool       Date:  1976-05

3.  Response to skin allografts in Xenopus laevis following thymectomy at early stages of lymphoid organ maturation.

Authors:  J D Horton; M J Manning
Journal:  Transplantation       Date:  1972-08       Impact factor: 4.939

4.  Effects of concanavalin A on the in vitro responses of mouse spleen cells to T-dependent and T-independent antigens.

Authors:  D M Jacobs
Journal:  J Immunol       Date:  1975-01       Impact factor: 5.422

5.  Subpopulations of splenic T cells regulating an antihapten antibody response. I. Helper and amplifier cells.

Authors:  D Y Muirhead; G Cudkowicz
Journal:  J Immunol       Date:  1978-02       Impact factor: 5.422

6.  Phenotypic restriction of antigen-binding specificity on immunized amphibian spleen cells.

Authors:  L N Ruben; B F Edwards
Journal:  Cell Immunol       Date:  1977-10       Impact factor: 4.868

7.  Effect of concanavalin A on lymphocyte interactions involved in the antibody response to type III pneumococcal polysaccharide. II. Ability of suppressor T cells to act on both B cells and amplified T cells to limit the magnitude of the antibody response.

Authors:  R B Markham; N D Reed; P W Stashak; B Prescott; D F Amsbaugh; P J Baker
Journal:  J Immunol       Date:  1977-09       Impact factor: 5.422

8.  The role of accessory cells in polyclonal T cell activation. I. Both induction of interleukin 2 production and of interleukin 2 responsiveness by concanavalin A are accessory cell dependent.

Authors:  T Hünig; M Loos; A Schimpl
Journal:  Eur J Immunol       Date:  1983-01       Impact factor: 5.532

9.  Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

Authors:  T Tada; T Takemori; K Okumura; M Nonaka; T Tokuhisa
Journal:  J Exp Med       Date:  1978-02-01       Impact factor: 14.307

10.  The use of bacterial lipopolysaccharides to show that two signals are required for the induction of antibody synthesis.

Authors:  J Watson; E Trenkner; M Cohn
Journal:  J Exp Med       Date:  1973-09-01       Impact factor: 14.307
View more
  1 in total

1.  Suppression in Xenopus laevis: thymus inducer, spleen effector cells.

Authors:  L N Ruben; A Buenafe; S Oliver; A Malley; K Barr; D Lukas
Journal:  Immunology       Date:  1985-01       Impact factor: 7.397
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.