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Literature DB >> 6234883

Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster beta-cells.

Abstract

We show that extracts of rat islets of Langerhans and of cloned hamster beta-cells (HIT-T15 cells) contain Ca2+-phospholipid-dependent protein kinase and endogenous protein substrates for the kinase. We purified Ca2+-phospholipid-dependent protein kinase from HIT-T15 beta-cells and report here its physical and kinetic properties.

Entities: Disease Species

Mesh：

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Year: 1984 PMID： 6234883 PMCID： PMC1153512 DOI： 10.1042/bj2190547

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

29 in total

Review 1. Inositol phospholipids and cell surface receptor function.

Authors: R H Michell
Journal: Biochim Biophys Acta Date: 1975-03-25

2. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

Authors: Y Takai; A Kishimoto; M Inoue; Y Nishizuka
Journal: J Biol Chem Date: 1977-11-10 Impact factor: 5.157

3. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors: M M Bradford
Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

4. Assay of cyclic AMP-dependent protein kinases.

Authors: J D Corbin; E M Reimann
Journal: Methods Enzymol Date: 1974 Impact factor: 1.600

5. Insulin release by isolated pancreatic islets of the mouse incubated in vitro.

Authors: E Coll-Garcia; J R Gill
Journal: Diabetologia Date: 1969-04 Impact factor: 10.122

6. Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases.

Authors: L M Siegel; K J Monty
Journal: Biochim Biophys Acta Date: 1966-02-07

7. Inter-relations between the phospholipids of rat pancreatic islets during glucose stimulation, and their response to medium inositol and tetracaine.

Authors: N Freinkel; C El Younsi; M C Dawson
Journal: Eur J Biochem Date: 1975-11-01

8. Phosphoinositide metabolism and insulin secretion from isolated rat pancreatic islets.

Authors: R S Clements; W B Rhoten
Journal: J Clin Invest Date: 1976-03 Impact factor: 14.808

9. Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase.

Authors: D L Severson; R M Denton; H T Pask; P J Randle
Journal: Biochem J Date: 1974-05 Impact factor: 3.857

10. Subcellular localization of the alterations in phosphatidylinositol metabolism following glucose-induced insulin release from rat pancreatic islets.

Authors: R S Clements; W B Rhoten; W R Starnes
Journal: Diabetes Date: 1977-12 Impact factor: 9.461

23 in total

Review 6. Secretory granules.

Authors: J C Hutton
Journal: Experientia Date: 1984-10-15

Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster beta-cells.

Review 1. Inositol phospholipids and cell surface receptor function.

2. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

3. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

4. Assay of cyclic AMP-dependent protein kinases.

5. Insulin release by isolated pancreatic islets of the mouse incubated in vitro.

6. Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases.

7. Inter-relations between the phospholipids of rat pancreatic islets during glucose stimulation, and their response to medium inositol and tetracaine.

8. Phosphoinositide metabolism and insulin secretion from isolated rat pancreatic islets.

9. Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase.

10. Subcellular localization of the alterations in phosphatidylinositol metabolism following glucose-induced insulin release from rat pancreatic islets.

1. Distinct mechanisms for two amplification systems of insulin release.

2. Protein kinase C: a family of isoenzymes with distinct roles in pathogenesis.

3. Glucose-induced translocation of protein kinase C in rat pancreatic islets.

Review 4. Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis.

5. Stimulation by glucose of cyclic AMP accumulation in mouse pancreatic islets is mediated by protein kinase C.

Review 6. Secretory granules.

Review 7. Protein phosphorylation in the pancreatic B-cell.

8. Properties of isolated human islets of Langerhans: insulin secretion, glucose oxidation and protein phosphorylation.

Review 9. Cytosolic free Ca2+ in insulin secreting cells and its regulation by isolated organelles.

10. An inhibitory role for polyamines in protein kinase C activation and insulin secretion in mouse pancreatic islets.