| Literature DB >> 6234145 |
P T Lan, A R Aedo, B M Landgren, E Johannisson, E Diczfalusy.
Abstract
The effect of a single dose of 150 mg of depo-medroxyprogesterone acetate (DMPA) on pituitary, ovarian and endometrial function was assessed in relation to the peripheral levels of the compound in 8 women. The levels of medroxyprogesterone acetate (MPA), follitropin (FSH), lutropin (LH), prolactin, estradiol (E2) and progesterone ( Prog .) were measured 3 times a week during a pretreatment (control) cycle and then daily during postinjection weeks 14-17, 22-25 and 30-33. An endometrial biopsy specimen was obtained during postinjection weeks 17, 25 and 33. In three out of 8 subjects the daily hormone assays carried out during postinjection weeks 30-33 indicated anovulatory periods; in these subjects peripheral blood was drawn daily during postinjection weeks 46-49 and a fourth endometrial biopsy was taken during week 49.Entities:
Keywords: Age Factors; Biology; Bleeding; Body Weight; Contraception; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Contraceptive Agents--administraction and dosage; Contraceptive Agents--analysis; Contraceptive Agents--pharmacodynamics; Endometrial Effects; Endometrium; Estradiol; Examinations And Diagnoses; Family Planning; Follicle Stimulating Hormone; Genitalia; Genitalia, Female; Histology; Laboratory Examinations And Diagnoses; Laboratory Procedures; Luteinizing Hormone; Medroxyprogesterone Acetate--administraction and dosage; Medroxyprogesterone Acetate--analysis; Medroxyprogesterone Acetate--pharmacodynamics; Menstrual Cycle; Metrorrhagia; Obesity; Ovulation Detection; Physiology; Pregnancy Rate; Progesterone; Prolactin; Reproductive Control Agents; Urogenital System; Uterus
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Year: 1984 PMID： 6234145 DOI： 10.1016/0010-7824(84)90054-4
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375