| Literature DB >> 6233177 |
R Siegberg, C G Nilsson, U H Stenman, O Widholm.
Abstract
The hormonal profiles and the effect of oral contraceptives (OCs) on 16 oligomenorrheic and 10 regularly menstruating adolescent girls were studied. Testosterone, androstenedione, dehydroepiandrosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, prolactin, and sex-hormone-binding globulin were determined on blood samples obtained during a control cycle, during OC treatment, and during the follow-up cycle after discontinuation of OC use. The oligomenorrheic girls had significantly higher concentrations of androstenedione and total and free testosterone than regularly menstruating girls during the control cycle. Sex-hormone-binding globulin concentrations were significantly lower in the oligomenorrheic group. Both in oligomenorrheic and regularly menstruating girls OC treatment caused a decrease in the mean concentrations of all hormones, except prolactin, to similar levels. For 2 to 4 weeks after treatment the oligomenorrheic girls had significantly lower levels of androstenedione, total and free testosterone, and luteinizing hormone than before treatment. In the control group there were no significant differences between pretreatment and posttreatment hormone concentrations. The risks and benefits of prescribing OCs for oligomenorrheic adolescent girls are discussed.Entities:
Keywords: Adolescent Pregnancy; Adolescents; Adolescents, Female; Age Factors; Androgens; Anthropometry; Biology; Body Weight; Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Methods--side effects; Dehydroepiandrosterone; Demographic Factors; Developed Countries; Diseases; Endocrine System; Estradiol; Estrogens; Europe; Examinations And Diagnoses; Family Planning; Fertility; Finland; Follicle Stimulating Hormone; Genital Effects, Female; Genitalia; Genitalia, Female; Gonadotropins; Gonadotropins, Pituitary; Growth; Hormones--analysis; Laboratory Examinations And Diagnoses; Laboratory Procedures; Luteinizing Hormone; Menarche; Menstrual Cycle--changes; Menstruation; Menstruation Disorders; Northern Europe; Oral Contraceptives--side effects; Physiology; Population; Population Characteristics; Population Dynamics; Progesterone; Prolactin; Reproduction; Reproductive Behavior; Reversibility; Scandinavia; Testosterone; Urogenital Effects; Urogenital System; Youth
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Year: 1984 PMID： 6233177 DOI： 10.1016/s0015-0282(16)47903-3
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329