Literature DB >> 6233159

Autoregulation of autoantibody synthesis in mercuric chloride nephritis in the Brown Norway rat. I. A role for T suppressor cells.

C Bowman, D W Mason, C D Pusey, C M Lockwood.   

Abstract

Mercuric chloride injections in the Brown Norway rat induce the transient formation of anti-glomerular basement membrane (GBM) autoantibodies. Transfer of spleen cells from convalescent animals, after circulating anti-GBM autoantibodies are no longer detectable, inhibits reinduction of the disease by HgCl2 in naive recipients. This inhibition is significantly less when the T suppressor cell population is depleted by the monoclonal antibody, MRC OX8 , before transfer. Our studies suggest a role for T suppressor cells in autoregulation in this animal model of autoimmune nephritis and may form a basis for the design of specific therapy for anti-GBM disease in man.

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Year:  1984        PMID： 6233159     DOI： 10.1002/eji.1830140515

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  23 in total

1.  Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low-responders and a shift of the interleukin profile.

Authors:  H Hu; M Abedi-Valugerdi; G Möller
Journal:  Immunology       Date:  1997-02       Impact factor: 7.397

2.  The role of endogenous steroid hormones in the generation of T helper 2-mediated autoimmunity in mercuric chloride-treated Brown-Norway rats.

Authors:  I A MacPhee; D R Turner; D B Oliveira
Journal:  Immunology       Date:  2000-01       Impact factor: 7.397

3.  Role of beta1 and beta2 subunits of the interleukin-12 receptor in determining T helper 1/T helper 2 responses in vivo in the rat.

Authors:  K M Gillespie; C C Szeto; V M Betin; P W Mathieson
Journal:  Immunology       Date:  2000-01       Impact factor: 7.397

4.  VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses.

Authors:  María Mittelbrunn; Ana Molina; María M Escribese; María Yáñez-Mó; Ester Escudero; Angeles Ursa; Reyes Tejedor; Francisco Mampaso; Francisco Sánchez-Madrid
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-19       Impact factor: 11.205

5.  Kinetics and pathogenicity of autoantibodies induced by mercuric chloride in the brown Norway rat.

Authors:  C D Pusey; C Bowman; A Morgan; A P Weetman; B Hartley; C M Lockwood
Journal:  Clin Exp Immunol       Date:  1990-07       Impact factor: 4.330

6.  HgC12 induces T and B cells to proliferate and differentiate in BN rats.

Authors:  L Pelletier; R Pasquier; C Guettier; M C Vial; C Mandet; D Nochy; H Bazin; P Druet
Journal:  Clin Exp Immunol       Date:  1988-02       Impact factor: 4.330

Review 7.  Experimental mercury-induced glomerulonephritis.

Authors:  L Pelletier; F Hirsch; J Rossert; E Druet; P Druet
Journal:  Springer Semin Immunopathol       Date:  1987

8.  A role for alphabeta T cells in the resistant phase of the Brown Norway rat model of vasculitis.

Authors:  C S Vinen; D R Turner; D B G Oliveira
Journal:  Clin Exp Immunol       Date:  2005-04       Impact factor: 4.330

9.  A central role for the mast cell in early phase vasculitis in the Brown Norway rat model of vasculitis: a histological study.

Authors:  Catherine S Vinen; David R Turner; David B G Oliveira
Journal:  Int J Exp Pathol       Date:  2004-06       Impact factor: 1.925

10.  Cyclosporin A induces long-term unresponsiveness in mercuric chloride-induced autoimmune glomerulonephritis.

Authors:  J Aten; C B Bosman; E De Heer; P J Hoedemaeker; J J Weening
Journal:  Clin Exp Immunol       Date:  1988-08       Impact factor: 4.330
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